Rheumatoid Arthitis 9/27

Question 1

Rheumatoid Arthitis

Answer 1

Chronic Inflammatory
disorder
◦Primarily affects joints
◦Also affects other organs

Question 2

Articular Cartilage

Answer 2

connective tissue at the ends of bones to provide a protective cushion

Question 3

Synovial Membrane

Answer 3

made of cells that produce synovial fluid and remove debris.

Question 4

Synovial Fluid

Answer 4

viscous substance that lubricates the joint and reduces friction

Question 5

Articular Capsule

Answer 5

Provides Support to the Joint
-Connects directly to the periosteum (the outer layer of the bone)

Question 6

Blood Vessels and Lymphatic Vessels

Answer 6

vessels that run through the synovial membrane

Question 7

HLA-DR

Answer 7

the susceptibility genes; a specific type of Class II MHC molecule associated with rheumatoid arthritis because it encodes the shared epitopes

Question 8

Shared Epitopes

Answer 8

specific amino acid sequences found on certain proteins that can trigger an immune response. In rheumatoid arthritis, there is a shared epitope on a region of the HLA-DR molecule. In RA, the shared epitope binds to citrullinated proteins

Question 9

Shared epitopes- rheumatoid impact

Answer 9

increases the risk of rheumatoid arthritis by binding to citrullinated proteins, initiating an immune response.

Question 10

Citrullination

Answer 10

a post-translational modification in which arginine is converted to citrulline

no longer recognize the protein as a self antigen.

Question 11

PAD enzymes

Answer 11

Peptidylarginine Deaminases (PADs)
catalyze arg–> citrulline