Alzheimers disease

Question 1

True of alzheimer’s/dementia

Answer 1

alzheimer’s always equals dementia

Question 2

Not true of alzheimer’s/dementia

Answer 2

dementia doesn’t always correlate to alzheimer’s

Question 3

pathway of AD

Answer 3

hippocampus- cerebral cortex-frontal lobe- total takeover

Question 4

early onset alzheimers

Answer 4

before age 65 (family history)

Question 5

Late onset alzheimers

Answer 5

after age 65 (point or unknown mutation)

Question 6

Amyloid precursor proteins

Answer 6

a transmembrane protein that plays a key role in the development and function of the nervous system

Question 7

amyloid precursor proteins lead to…

Answer 7

amyloid beta plaques

Question 8

APP normal secretase

Answer 8

alpha, gamma

Question 9

APP mutated secretase

Answer 9

BETA, gamma

Question 10

Amyloid beta plaques

Answer 10

not cleaved as small, block neurotransmitters in the neural synaptic junction

Question 11

alpha/ gamma secretase normal function

Answer 11

cleave ABP into smaller plaques and recycled via microglial cells, astrocytes, APO-lipoprotein epsilon

Question 12

tau protein normal physiology

Answer 12

hold microtubules that make up axon in the neuron

Question 13

Tau tangles

Answer 13

kinase phosphorylates tau protein causing tangles that weaken the axon

Question 14

Genetic risk factors down syndrome

Answer 14

chromosome 21-> coding region for APP

Question 15

Presenlin genes 1 & 2 (PSEN1)

Answer 15

Code for Subunits Associated With Alpha and Gamma Secretase

Question 16

APOE 4 Genes

Answer 16

code for apo-lipoprotein

Question 17

APOE 4 vs 3 & 2

Answer 17

isoforms–3 and 2 have lower cholesterol levels

apoe 4 has high cholesterol levels