Osteoporosis and Osteomalacia

Question 1

Bone marrow matures into

Answer 1

osteoblasts/ osteoclasts

Question 2

bone marrow–> osteoblasts

Answer 2

Mesenchymal Stem cells >Osteoprogenitor >Osteoblasts

Question 3

bone marrow–> osteoclasts

Answer 3

Hematopoietic Stem cells > Monocyte precursor > (need RANKL)
Osteoclast

Question 4

what surrounds bone marrow

Answer 4

spongy bone made of multiple
trabeculae

Question 5

Osteons

Answer 5

• Haversian Canal- contains blood vessels and nerves
• Lamellae- made of collagen & hydroxyapatite (calcium
  phosphate matrix)

Question 6

Bone remodeling physiology 1+2 osteoblast

Answer 6

1- Osteoblast recognizes damage
2-Osteoblast secretes RANKL which binds to monocyte precurso

Question 7

Bone remodeling physiology 3+4 osteoclast

Answer 7

3- Monocyte precursor cell differentiates into osteoclast
4- Osteoclast secretes collagenase (breaks down collagen) and HCl
(breaks down hydroxyapatite and Ca2+ enters bloodstream

Question 8

Bone remodeling physiology 5 osteoblast

Answer 8

5- Osteoblast secretes osteoprotegerin which binds to RANKL to
prevent RANKL signal to monocyte precursor cell

Question 9

Bone remodeling physiology 6-8

Answer 9

6- Osteoclasts go through apoptosis
7- Osteoblasts secrete osteoid seam (mainly made of collagen)
8- Calcium & phosphate stick to osteoid seam reforming
hydroxyapatite