Structure of proteins III

Question 1

What affect do carbamates have on Hb

Answer 1

stabilize T state, promote O2 release

Question 2

what happens when you reduce pH

Answer 2

promote O2 relase

Question 3

what is the most common form of hemoglobin in adults

Answer 3

alpha2beta2 hemoglobin

Question 4

what other type of Hb does adult blood contain

Answer 4

alpha2delta2

Question 5

what is the predominate form of Hb in fetus during second and third trimester

Answer 5

alpha2gamma2

Question 6

what is unique about HbF

Answer 6

histidine residency is replaced by serine, has incrased oxygen affinity

Question 7

what is Hbsaki/Hbgenova

Answer 7

proline is introduced into an alpha-helical section

Question 8

what is Hbcowtown

Answer 8

amino acid substituion destrabilizes the T form of molecule

Question 9

methemoglobin

Answer 9

Fe2+ is oxidized to Fe3+

Question 10

what substituion takes place in sickle cell

Answer 10

glutamate by valine

Question 11

protein domain

Answer 11

substructure produced by any part of a polypeptide chain that can fold independently into a compact, stable structure

Question 12

what are individual domains often connected by

Answer 12

flexible linkkers

Question 13

what is collagen made up of

Answer 13

glycine
alanine
proline
hydroxyproline

Question 14

what are the most abundant proteins in the body

Answer 14

collagen

Question 15

what is collagen

Answer 15

glycoproteins of CT

Question 16

what is the structure of collagen

Answer 16

triple helical units

Question 17

how does the collagen helix twist

Answer 17

twists to the left, one turn every 3 residues

Question 18

what is the repeating sequency of colalgen

Answer 18

gly - proline - hydroxyproline

Question 19

where are glycine residues in tropocollagen

Answer 19

in the center, allowing a tight fit

Question 20

how is the triple helix stabilized

Answer 20

interchain hydrogen bonds

Question 21

how is hydroxyproline residues important in collagen

Answer 21

form additional hydrogen bonds, vital for stability

Question 22

formation of hydroxyproline an dhydroxylysine requires what

Answer 22

Fe2+. ascorbate, and alpha ketoglutarate

Question 23

what catalyzes the formation of hydroxyproline

Answer 23

prolyl hydroxylase

Question 24

what is happening in scury

Answer 24

lack of ascorbate precents formation of hydroproline and hydrozylysine, so collagen can’t form stable helcies and CT is all fucked up

Question 25

symptoms of scurby

Answer 25

leg pain, irritability, dry skin, bruising

Question 26

osteogenesis imperfecta

Answer 26

brittle bone diseases

can be lethal, or the pt can barely notice it