2nd messengers I Flashcards
4 classes of cellular signaling molecules
hormones
local mediators
neurotransmitters
growth factos
growth factos
signaling molecules that regulate cell proliferation and differentiation
hormones
have regulatory effects on specific organs or tissues at a site distrant from hormone secretion
how do hydrophilic hormones work
bind to plasma membrane receptor
either generate intracellular second messenger or activate receptor enzymatic acitivty
what do hydrophilic hormones generally result in
changes in activity of meabolic enzymes (typically rapid)
what are lipophilic hormones often derived from
cholesterol
function of lipophlic hormones
pass through plasma membrane and bind receptors in nucleus or ceyptoplasm
what does binding of lipophilic hormones result in
altered transcription (slower response)
how do water soluble hormones mainly function
binding to specific receptors
GDP bound form is waht
inactive
GTP bound form is what
active
GTPase
hydrolyze GTP to GDP and can turn themselves off
what happens when the G protein gets acitived
dissociation of the alph asubunit from the beta-gamma dimer
G-proteins frequenctly activate proteins that generate what
intracellular second messengers
Gs generally does what
stimulates activity of enzymes
Gi generally does what
inhibit activity of certain enzymes
