Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biochem 1 > ETC > Flashcards

ETC Flashcards

1
Q

what is the major ATP generating organelle in the cell

A

mitochondrion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

inner membrane of mitochondria sturcture

A

highly invaginated, high surface area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

mitochondrial matrix

A

internal soluble compartment of the mitochondrion, bounded by inner membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the out membrane composed of

A

half protein, half lipis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is inner membrane composed of

A

80% protein, 20% lipid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

outer membrane permeability

A

highly permeable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

inner membrane permeability

A

less permeable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what does the matrix contain

A

soluble enzyme system, PDH complex, enzymes for fatty acid beta oxiation, some urea cycle enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ETs

A

series of chain of electron carries in inner mitochondrial membrane that funnel electrons from reduced substrates to molecule oxygen to form water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what happes to free energy in ETS

A

loses free energy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

oxidative phosphorylation

A

coupling of oxidation of metabolic substrates by ETS to phosphorylation of ADP to form ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What proteins are in the ETS

A

dehydrogenases, iron containing proteins, nonheme-iron proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what lipids are in the ETS

A

coenzyme Q

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the dehydrogenases of the ETS

A

succinate dehydrogenase, NADH dehydrogenase, fatty acyl-CoA dehydrogase, glycerol 2 phosphate dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

function of NADH dehydrogase

A

oxidizes NADH to NAD+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

function of fatty acyl-CoA dehydrogenase

A

catalyzes the intiral step in beta oxidation of fatty acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the iron contain proteins in ETS

A

cytochromes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

waht is uniwue about the iron of cytochromes

A

undergoes fluctuation between teh reduced and oxidized state (Fe2+, Fe3+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what are the nonheme iron proteins in ETS

A

they contain irson complexed to sulfide ions

20
Q

complex I

A

NADH-CoA reductase

21
Q

Comples II

A

succinate CoQ-reductase

22
Q

Complex III

A

CoQH2 cytochrome c reductase

23
Q

complex IV

A

cytochrome oxidase

24
Q

what are inhbitors of complex IV

A

cyanide CO

25
Q

which complex contains Cu that flucates between Cu2+ and Cu3+

A

complex IV

26
Q

which complexes yield ATP

A

I, III, IV

27
Q

the amount of energy liberated via ETS would form how many ATPs under standard conditions

A

7

28
Q

chemiosmotic model

A

free energy derived from ETS direces active transport system that pumps H+ out of mitochondrial matrix, establishing electrochemical gradient

29
Q

what are the sites of proton pumping in the ETS

A

I, III, IV

30
Q

what is complex V

A

ATP synthase, couples the re-entry of protons to the synthesis of ATP

31
Q

what is the F0 unit

A

multisubunit, transmembrane complex that forms a proton channel through the membrane

32
Q

what is the F1 component

A

multisubunit structure that extends into the matrix and forms the catalytic moiety invovled in the actual synthesis of ATP from ADP+Pi

33
Q

function of uncouplers of ox phos

A

provide an alternate froute for re-entery of protons to mitochondral matrix

34
Q

examples of uncoupler of ox phos

A

DNP

35
Q

where is brown fat

A

hibernating animals, newborns

36
Q

what is uniwue about brown fat

A

contains mitochondria that have biological uncouplign protein, helps the organism stay warm

37
Q

how does ATP get to cytosaol

A

adenine nucleotide translocase that exchanges ATP for ADP

38
Q

what inhibits adenine nucleotide translocase

A

atractyloside

39
Q

symptoms of LHON

A

sudden onsite blindness in young adults due to death of optic nerve

40
Q

what is LHON due to

A

mutation in complex I

41
Q

MERRF is caused by

A

point mutaiton in mitochondrial gene for lysin tRNA

42
Q

symptoms of MERRF

A

myoclonus and ataxia with generalized seizures

43
Q

symptoms of MELAS

A

muscle has ragged red ribers, but cytochrome oxidase is near normal

44
Q

what is MELAS caused by

A

point mutation in gene for leucine tRNA

45
Q

what does DNP do

A

uncoupling of ox phos

Biochem 1 (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions