Protein and Amino Acid Metabolism II

Question 1

glucose alanine cycline

Answer 1

pyruvate generated by glycolysis in muscle, convereted to alanine
alanine relased into blood, taken up by liver
in liver alanine converted back to pyruvate which is sued for gluconeogensishow is aspartate syntheizedfrom OAA by AST

Question 2

difference between asparagine synthesisi and glutamine sysnthesise

Answer 2

asparagine synthease uses amide nitrogen of glutamine, but amide of glutamine is formed from an ammonium ion

Question 3

where is ALT found primarily

Answer 3

liver

Question 4

elevation of AST indicates waht

Answer 4

liver or heart damage

Question 5

what is a mjor source of glycin in the diet

Answer 5

colalgen

Question 6

how are serine and glycine interconverted

Answer 6

serine hydroxymethyltransferase

Question 7

what does the serine to glycine reaction require

Answer 7

PLP

Question 8

what is THF derived from

Answer 8

foalte

Question 9

what is the function of THF

Answer 9

acceptor for 1 carbon groups

Question 10

one carbon pool

Answer 10

one carbon groups attached to THF

Question 11

what is the most oxidized form of THF

Answer 11

N10 formyl THF

Question 12

what is the most reduced form of THF

Answer 12

N5 formylTHF

Question 13

what form of THF tends to accumulate in teh body

Answer 13

N5methyl THF

Question 14

what is a mjor source of one carbon groups in the one carbon pool

Answer 14

serine

Question 15

why is cysteine unique

Answer 15

only amino acid that can be reversible reduce and oxidized

Question 16

homocystinuria

Answer 16

elevated levels of homocystine in the urine

Question 17

clinical features of homocystinuria

Answer 17

dislocation of optic lens
osteoporsis
problems with long bones
intellectual disablity

Question 18

how do you treat homocystinuria

Answer 18

low methionine diet

Question 19

can tyrosine be converted to phenylaline

Answer 19

no

Question 20

how is tyrosine made from phenylketounira

Answer 20

phenylalaine hydroxylase

Question 21

what is happening in PKU

Answer 21

unable to convert phenylalaine to tyrosine

Question 22

symptoms of PKU

Answer 22

intellectual disability, seizures, hypopigmentation, skin rases

Question 23

how does PKU wok

Answer 23

phenyalailne competitviely inhibits transport across blood brain barrier of othe ramino acids

Question 24

how do you treat PKU

Answer 24

low phenylalaine diet beging before the kid is 3 weeks old

Question 25

can people with PKU have aspartame

Answer 25

no