Protein and Amino Acid Metabolism V

Question 1

what do you need for the synthesis of cretine

Answer 1

glycine, arginine, SAM

Question 2

when is the phosphorylation of creatine favored

Answer 2

when ATP conc in muscle is high

Question 3

is the phophate group transfer potential of creatine phosphater higher or lower than that of ATP

Answer 3

higher

Question 4

what happens allows for continued muscle contraction during an intense burst o faerobic activity

Answer 4

regen of ATP from creatine phospahte and ADP

Question 5

what releases creatinine

Answer 5

muscel cells

Question 6

how is creatinine excreted

Answer 6

urine

Question 7

amount of creatinine excreted each day is propertion to waht

Answer 7

muscle mass

Question 8

creatinine is an indicator of what

Answer 8

kidney function

Question 9

symptoms of children suffering from defect of enzyme of creatine synthesis/uptake

Answer 9

hypotonia, neurlogical symtoms

little skeletal/cardiac muscle pathology

Question 10

how do you treat children with creatine synthesis problem

Answer 10

dietary supplementation of creatine

Question 11

what catecholamine signaling molcules are derived from tyroosine

Answer 11

dopamine
norepinephrine
epinephrine

Question 12

how do you get from tyrosin to epinephrine

Answer 12

tyrosine –> DOPA —> dopamine —> NE —-> epinerphee

Question 13

what are tyrosines contained in

Answer 13

thryoglubulin

Question 14

what is thyrglobin degreated in

Answer 14

lysosomes

Question 15

where does synthesis of melanin take place

Answer 15

melanocytes

Question 16

how do you get synthesis melanin

Answer 16

tyrosine —-> DOPA —–> dopaquinone —–>melanin

Question 17

what is required for the conversion of NO to epinephrine

Answer 17

SAM

Question 18

what casues oculocuaneous albinism type 1

Answer 18

loss of function of tyrosinase due to mutation in TYR gene

Question 19

what is serotonin derived from

Answer 19

tryptophan

Question 20

where is serotonin most abudant

Answer 20

platelets and GI tract

Question 21

where is serotonin produced

Answer 21

pineal gland

Question 22

what does the melatonin synthesis reaction require

Answer 22

SAM

Question 23

what does tryptophan convert to by the liver

Answer 23

niacin

Question 24

what converts tryptophan to niacin

Answer 24

IDO

Question 25

how is GABA produced

Answer 25

decarbozylation of glutamate

Question 26

how do you get histamine

Answer 26

decarboxylation of histidine

Question 27

what is glutathione

Answer 27

tripeptide with sequence glu-cys-gly

Question 28

what is gamma glutamyl linkage resistant to

Answer 28

proteolysis

Question 29

what type of bond holds glutathione together

Answer 29

gamma glutamyl

Question 30

what is unique about glutathion

Answer 30

does not require mRNA template

Question 31

where is glutathione made principally

Answer 31

liver

Question 32

function of glutathione

Answer 32

intracecllular reducing agent - specifally peroxidies

Question 33

when glutathione is oxidized what does it form

Answer 33

dimer GSSG

Question 34

where is glutathione rich

Answer 34

red blood cells

Question 35

why is glutathione high in RBCs

Answer 35

maintains plasma membrane integrity by reducing peroxides formed during oxygen transport

Question 36

what are the glutathione s transferases involved in

Answer 36

detox process