Lipids V Flashcards
What does transport of lipids require
assembly of lipoprotein complex with hydrophilic surface and lipophilic core
function of HSL
release FFA into circulation from storage triglycerides
what hormones does HSL response to
insuline
cortisol
glucagon
how does insulin affect HSL
inhibit
how does cortisol affect HSL
induces
how does glucagon affect HSL
stimulate
function of apoproteins of A class
activators of LCAT
function of apoproteins of B class
strucutral proetins that give lipoporetin its shap
function of apoportins of C class
modulat function of LPL.
function of apoporteins of E class
removal of lipid-depleted lipoproteins from circulation
functino of enterocytes
resynthesize tricyglycerols and pack them into chylomicrons for distribution throughout the body
where do newly synthesized chylomicrons go
secreted into lymphatic system and enter blood through thoracic duct
function of chylomicrons
distribution of dietary lipids trhough the body
functino of lipoprotein lipases on surface of target cells
cleave triacyclglycerols and liberate FFA from chylomicrons
what removed chylomicron remnants from circulation
liver
what binds to LDL recpetos on surface of liver cell
apoporteins ApoB48 and ApoE
VLDLs
synthesized by liver to distribute lipids into peripheral tissue
what happens when VLDLs lose lipds
turn into IDLs
what happens when IDLs lose lipids
turn into LDLs
when does blood conc of LDL increase
if liver sends out more lipids in VLDL particules than the body can consum
what Apoportin does VLDLs synthesize around
ApoB100
what are VLDLs capable of
extracting cholesteryl esters from cells
HDL function
reverse cholesterol transport from peripheral tissues to liver
how do HDL particules acquire choelsteral from periphal tissues
- choelsteral transport by ABCA-1
2. choelteral transferred to HDL particle adn esterfiled by LCAT.
