Structure and function of the NS- Spina bifida Flashcards
split into
autonomic (sum and para) and somatic
Spinal nerves are part of the
somatic nervous system
how many pairs of spinal nerves
31- innovate different parts of your body
–> made up of sensory (afferent) and motor (efferent) neurons
afferent
sensory
efferent
motor
Autonomic NS is made up of
sympathetic and parasympathetic NS
brain stem
autonomic NS
sympathetic innovation
fight or flight- thoracolumbar
parasympathetic
- rest and digest- craniosacrel
autonomic NT
noradrenaline or adrenaline
what innovates thoracic region
sympathetic
what innovates neck and bottom part of the back
parasympathetic
somatic
motor function
main features of the somatic nervous system
- always 1 efferent motor neurone from CNS to target organ
- cell body in the CNS
- NT released from terminal bouton- alway ACh in somatic
NT in somatic NS is always
ACh
receptor on target organ in somatic NS is always
nicotinic - inotropic receptor (Na+ channel- ligand gated)
bouton=
presynaptic knob
do somatic neurones have pre-and post ganglionic neurones
no- just one efferent motor neurone
sympathetic neurones structure:
1 short preganglionic neurone and a longer post ganglion neurone.
sympathetic neurones always release … from preganglionic neurones
ACh- always an ACh nicotinic receptor
sympathetic postganglionic always have an
adrenoreceptor (noradrenaline released from postgwanglonic neurone terminal bouton)-
adrenoreceptor found on sympathetic post ganglionic neurone is
metabotropic- GPCR- longer response
heart- sympathetic
B1 adrenergic receptor (GalphaS)- ionotropy, chemotrophy and luistropy
luistropy
rate of mycardio relaxation
bronchiole- sympathetic
B2 adrengeric receptor (GalphaS)- relaxes
parasympathetic neurone structure
2 neurones cranial and sacral
- 1 long preganglionic neurone from CNS
- 1 short postganglionic neurone- ACh released
receptor on post ganglionic parasympathetic neurone is
nicotinic ACh
ganglia in parasympathetic neurone is found
near effector organ
what kind of receptor is found on parasympathetic target organ
muscarinic acetyl choline receptors- metabotropic- GPCR
M2 heart- relaxation
GalphaI
M3 exocrine glands
GalphaQ
GPCR
7 transmembrane
3 subunits-heterotrimeric, alpha, beta, gamma
GalphaS
activates adenylate cyclase- increase in cAM- activates PKA
GalphaI
inhibits adenylate cycle- less cAMP
GbetagammaO
activates K_ channels and inhibits Ca2+ channels
GalphaO
activates phospholipase C: increase in IP3
dermatomes
areas of the skin innovated by the 1 spinal nevers
C1 has no
dermatomes
CN X
vagus nerve (heart, stomach, small and large intestine and bronchiole tree)
CN III
eyes
CN VII
face
CN IX
mouth, taste, salivation
S2-S4
parasympathetic
-pelvic splanchnic
T1-L3 (thoracic region)
sympathetic