Gs Flashcards
1
Q
S for
A
stimulatory
2
Q
stimulates
A
adenylyl cyclase
3
Q
adenylyl cyclase
A
produces cAMP from ATP
4
Q
increase in cAMP increases
A
PKA
5
Q
PKA
A
protein phosphorylation and activation of downstream proteins
6
Q
pathway
A
1) ligan binds
2) GDP is exchanged of GTP
3) y+B dissociates
4) Gs activates adenylyl cyclase which produces ATP from cAMP
5) cAMP activates PKA
6) PKA activation of downstream signaling
7
Q
Gs receptors
A
B1 adrenergic, B2 adrenergic, B3 adrenergic, thyrotropin receptor, Glucagon receptor
8
Q
B1 adrenergic
A
- increase cardiac output, by increasing heart rate. (noradrenaline)
- renin secretion
9
Q
B2 adrenergic
A
- fight or flight response
- smooth muscle relaxation in the lungs (noradrenaline)
10
Q
B3 adrenergic
A
lipolysis in adipose tissue
11
Q
glucagon receptor
A
causes the breakdown of glycogen when adrenaline binds
12
Q
gene expression
A
PKA phosphorylates DNA binding elements
