Gi Flashcards
1
Q
i for
A
inhibits
2
Q
inhibits
A
adenylyl cyclase
3
Q
inhibited adenylyl cyclase means
A
less cAMP
4
Q
less cAMP means less
A
PKA- less down stream reactions
5
Q
pathway
A
1) Gi inhibits adenyl cyclase (in the men)
2) less ATP converted to cAMP
3) less PKA
4) less phosphorylation of proteins downstream- intracellular signaling pathways inhibited
5) beta-gamma complex interacts with GIRK
6) opens K+ channels
7) hyperpolarisation
6
Q
GIRK
A
gated inwardly rectifying K+
7
Q
which receptors do Gi work on
A
M2, M4, Alpha 2 adrenoreceptor, opioid receptors
8
Q
M2 muscarinic ACh receptor
A
(the heart) decreases cardiac output, by decreasing HR, contractile force and speed of relaxation
9
Q
Alpha2 adrenergic receptor
A
- vasoconstriction of blood vessels
- autonomic NS- decrease in NT released
- inhibition of NA, ACh and insulin
