Stable Coronary Artery Disease

Question 1

Risk Factors

Answer 1

Hypertension

Smoking

Hyperlipidaemia

Hyperglycaemia

Male

Post-menopausal females

Question 2

Common pathology of SIHD is

Answer 2

atherosclerosis

Question 3

Drugs can help to reduce the myocardial oxygen imbalance by reducing cardiac workload by

Answer 3

reducing HR

reducing myocardial contractility

reducing afterload

Question 4

Drug therapies include

Answer 4

beta adrenoreceptor antagonists

ivabradine

calcium channel blockers (vasodilators)

nitrates (vasodilators)

aspirin, clopidogrel

Question 5

Beta Blockers examples

Answer 5

bisoprolol

atenolol

Question 6

Beta blockers function

Answer 6

decrease HR, contractility, systolic wall tension

Question 7

Calcium channel blockers examples

Answer 7

diltiazem

verapamil

amlodipine

Question 8

calcium channel blocker function

Answer 8

prevents calcium influx into mycocytes

vasodilation

reduce HR

Question 9

Why NOT use nifedipine (a calcium channel blocker) immediately?

Answer 9

evidence of acute MI or stroke

Question 10

Nitro vasodilators examples

Answer 10

glycerol trinitrate (GTN)

isosorbide mononitrate

isosorbide dinitrate

Question 11

Nitrates receive angina by

Answer 11

arteriolar dilatation

Question 12

GTN is good to use as it

Answer 12

avoids first pass metabolism

Question 13

IV nitrates are used when…

Answer 13

treatment of unstable angina

usually with heparin

Question 14

Ivabradine

Answer 14

selective sinus node channel inhibitor

reduces MI in patients with angina

Question 15

Aspirin and clopidogrel

Answer 15

anti-platelet aggregation

Question 16

Treatment regime for SIHD

Answer 16

beta blocker

rate limiting CCB

dihydropiridine CCB

Aspirin

Statin

Long acting nitrate

Question 17

Drugs for secondary prevention of CVD

Answer 17

Aspirin (75mg daily) (can use clopidogrel if intolerant to aspirin)

ACE inhibitors

Statin treatment

Treatment for high blood pressure