Regulation of HR and SV Flashcards
Sympathetic nerves release
noradrenaline
noradrenaline and adrenaline both act on
b1 receptors in the SA node
Noradrenaline acting on B1 receptors in the SA node leads to
an increase in heart rate
tachycardia
parasympathetic NS releases ….. form the …..
ACh
Vagus nerve
ACh acts on muscarinic receptors on the
SA node
ACh acting on the SA node will
decrease heart rate
bradycardia
Bradycardia
decreased HR
Tachycardia
increased HR
Starling law states that the energy of contraction is proportional to the
initial length of the cardiac muscle fibre
Preload
initial stretching of cardiomyocytes before contraction
Stroke volume
volume of blood from left ventricle in one beat
In vivo, afterload is set by the
arterial pressure against which the blood is expelled
If Total peripheral resistance increases, then stroke volume will
decrease
after load is the
load against which the muscle tries to contract
capacitance vessels (veins and venules) affect
preload
resistance vessels (arterioles) affect
AFTERLOAD
adrenaline is released form the
adrenal medulla
adrenaline and noradrenaline act on SV by
increasing contractility
gives stronger but shorter contraction
Parasympathetic system effects on SV
very little
Cardiac Output equation
CO = HR x SV
Increasing HR with an electronic pacemaker causes a small increase in CO but then decreases SV. Why?
shortened cardiac interval cuts into the rapid filling phase
reduced EDV will reduce
preload
and therefore SV
HR increases by
decreased vagal tone
increased sympathetic tone
contractility increases by
increased sympathetic tone
Venous return increases via
venoconstriction