SPECIAL TISSUES II

Question 1

alterations of the levels of various factors result in an increase of osteoclastic activity over osteoblastic activity

loss of estrogen is critical

Answer 1

osteoporosis

Question 2

strongly associated with mutations of fibroblast growth factor receptor 1

defective genes are _________ and ________

Answer 2

pfeiffer syndrome
FGFR1; FGFR2

Question 3

autosomal dominant
50% due to spontaneous mutation
due to mutation of FGFR2 at chromosome 10

Answer 3

bone-crouzon syndrome

Question 4

bone-crouzon dermoskeletal syndrome

due to mutation of _________

Answer 4

FGFR-3

Question 5

Cartilage

principal protein is type __ collagen

_____ is the major proteoglycan

Answer 5

cartilage