LIPID METABOLISM 3

Question 1

cholesterol biosynthesis steps

Answer 1

acetyl coA to mevalonate
mevalonate to 2 activated isoprenes
condensation of isoprenes to form squalene
squalene to four ring steroid nucleus

Question 2

1st rate limiting step of synthesis of melavonate from acetyl coa

enzyme:
cofactor
product

Answer 2

HMG CoA reductase
NADPH
mevalonate

Question 3

converstion of mevalonate to 2 activated isporines

sequential phosphorylation of mevalonated by _________ using ATP

Answer 3

3 kinases

Question 4

regulatory enzyme of cholesterol biosynthesis

catalyzes first committed step in pathway

Answer 4

HMG Coa Reductase

Question 5

three regulatory mechanisms of enzyme HMG CoA reductatse

Answer 5

repression of transcription
control of degradation
feeding regulatory system

Question 6

HMG CoA reductase has 2 forms

Answer 6

unphosphorylated - active
phosphorylated - inactive

Question 7

in the skin when 7 dehydrocholsterol gets exposed to UV light it will be converted to _____

Answer 7

cholecalciferol or vitamin D

Question 8

prenatal ____________ exposure in females has a masculinizing effect on the development of the external genitalia

the condition is called __________

Answer 8

androgen
congenital adrenal hyperplasia

Question 9

____________- transfers fatty acid of CoA to C3 hydroxyl group of cholesterol

Answer 9

ACAT

Question 10

excess cholesterol is stored as _________ in cytosolic lipid droplets

Answer 10

cholesterol esters

Question 11

final bile acids are

Answer 11

chenocolic acid and cholic acid