CARBOHYDRATE METABOLISM (KREBS CYCLE)

Question 1

REACTION 1
condensation reaction: acetyl-CoA + oxaloacetate = citrate

enzyme is __________

Answer 1

citrate synthase

Question 2

the 1st reaction is the rate-limiting step and is a major control point, it is an irreversible reaction

Answer 2

acetyl-CoA + oxaloacetate = citrate

Question 3

REACTION 2
dehydration/rehydration reaction

citrate to isocitrate the enzyme is __________

Answer 3

aconitase

Question 4

REACTION 3 isocitrate to alpha ketoglutarate and the enzyme is ___________

it is also a control point

Answer 4

isocitrate dehydrogenase

Question 5

in reaction 3 how many ATP is produced

isocitrate to alpha ketoglutarate
e: isocitrate dehydrogenase

Answer 5

2.5 is produced in reaction 3

Question 6

REACTION 4 alpha ketoglutarate to succinyl-CoA

the enzyme is ______________
it is a control point

Answer 6

alpha ketoglutarate dehydrogenase complex

Question 7

in reaction 4 how many ATP is produced

alpha ketoglutarate to succinyl-CoA
e: alpha ketoglutarate dehydrogenase complex

Answer 7

2.5 is produced in reaction 4

Question 8

REACTION 5 succinyl coA to succinate

it is an energy conserving reaction so _________ is produced
the enzyme is ___________

Answer 8

1 ATP

succinyl CoA synthase/succinic thiokinase

Question 9

REACTION 6 is a dehydrogenation reaction
succinate to fumarate the enzyme is ________________-

Answer 9

succinate dehydrogenase

Question 10

REACTION 6 will produce ______ ATP
it is a control point

succinate to fumarate

Answer 10

1.5 ATP is produced

Question 11

REACTION 8 is a dehydrogenation reaction
malate to oxaloacetate

NAD dependent
produced ________-

Answer 11

2.5 ATP