CARBOHYDRATE METABOLISM 2

Question 1

neuropsychiatric disorder caused by lack of thiamine in the diet which leads to transketolase inactivation

Answer 1

wernicke-korsakoff syndrome

Question 2

activated form of glucose

Answer 2

uridine diphosphate glucose

Question 3

action forms a alpha 1,4 glycosidic linkage between UDP glucose and terminal glucose residue of glycogen (glycogen primer required)

Answer 3

glycogen synthase

Question 4

branching enzyme for glycogen

Answer 4

amylo (1,4 -> 1,6) transglycosylase

Question 5

debranching enzyme known as _______ catalyzes the hydrolytic splitting of the a(1-6) linkages

Answer 5

amylo (1,6) glucosidase

Question 6

___________ activates glycogen synthase to promote glycogenesis, inhibits cAMP, glycogenolysis, and inactivates phosphorylase

Answer 6

insulin

Question 7

____________ & _________—- inhibits glycogen synthases to promote glycogenolysis, inhibits glycogenesis and activates phosphorylase

Answer 7

glucagon and epinephrine

Question 8

________ removes glucose units in alpgha 1,4 linkages during glycogenolysis

Answer 8

phosphorylase

Question 9

uronic acid pathway is the pathway for the conversion of glucose to _______

Answer 9

ascorbic acid (vitamin c)

Question 10

main function of uronic acid pathway is the production of UDP glucose and glucuronic acid (glucoronate)

AND __________ is the active form of glucuronic acid

Answer 10

UDP-glucoronate

Question 11

3 important enzymes of converting galactose to glucose

GAL, GAL, UDE

Answer 11

Galactokinase
Galactose 1 phosphate uridyl transferase
Uridine diphosphogalactose 4 epimerase