ENZYMES OF MI

Question 1

Catalyzes the interconversion of aspartate and a-ketoglutarate to
oxaloacetate and glutamate

Begins to rise after 6-8 hours

Answer 1

aspartate aminotransferase

Question 2

catalyzes the interconversion of lactic acid and pyruvic acid

peak at 48-72 hours
elevated for 10 days

Answer 2

lactate dehydrogenase

Question 3

associated with ATP regeneration in contractile system
peak at 12-24 hours

Answer 3

creatine kinase

Question 4

multiple forms of enzymes
catalyze the same reaction but differ in their physical properties

Answer 4

isoenzymes

Question 5

monomeric protein that is found in skeletal and cardiac muscle

earliest marker for myocardial injury

high sensitivity, poor specificity
rise at 1-3 hours
peak at 5-12 hours

Answer 5

myoglobin

Question 6

structural components of cardiac muscles (T and I)

Answer 6

troponins

Question 7

valuable tool for the diagnosis of AMI
useful for the assessment of early and late cardiac injury

Answer 7

tropinin T

Question 8

found in the myocardium
greater specificity compared to TnT

Confirmatory for AMI

Answer 8

TROPONIN I

Question 9

serine proteiase found in endothelial cells that line the blood vessels

Answer 9

tissue plasminogen activator

Question 10

also a serine protease
the primary physiological substrate is plasminogen which is an inactive enzyme form of serine protease

Answer 10

urokinase

Question 11

protein secreted by several species of streptococci
can bind to activate human plasminogen

Answer 11

streptokinase