LIPID METABOLISM 1

Question 1

clusters of lipids and proteins that are used as transport vehicles for fat

Answer 1

lipoproteins

Question 2

typical composition of lipoproteins contains

Answer 2

TG and cholesterol esters internally
Phospholipids externally
Apoprotein

Question 3

the largest lipoproteins
lowest in density due to high lipid/ protein ration

Answer 3

chylomicrons

Question 4

bad cholesterol
highest in cholesterol

Answer 4

low density lipoproteins

Question 5

2nd highest in TAGS as % of weight
has similar composition as the chylomicron

Answer 5

very low density lipoproteins

Question 6

good cholesterol
highest in density due to high protein/lipid ratio
contains very few TAGs; mostly cholesterol

Answer 6

high density lipoproteins

Question 7

chylomicron is synthesized in the ________

Answer 7

small intestine

Question 8

apolipoproteins embedded on the chylomicron

Answer 8

Apo B48, Apo E,A,C

Question 9

Main features of Chylomicron metabolism

initial apolipoproteins are

Answer 9

Apo B48 and Apo A

Question 10

Main features of Chylomicron metabolism

initial apolipoproteins acquired in circulation via HDL

Answer 10

Apo E and Apo C

Question 11

Half-life of chylomicrons

Answer 11

5-10 minutes

Question 12

Apo C activates the enzyme

Answer 12

lipoprotein lipase

Question 13

fate of glycerol after release from chylomicron and VLDL

glycerol release by _______
taken up by _____ and ____
converted into glycolytic intermediated ______

Answer 13

lipoprotein lipase
kidney and liver
dihydroxyacetone phosphate (DAHP)

Question 14

VLDL is synthesized in the ________

Answer 14

liver

Question 15

embedded VLDL are the apolipoproteins

Answer 15

Apo B100, Apo C, Apo E

Question 16

Half Life of VLDL

Answer 16

15-60 minutes

Question 17

Fate of VLDL conversion to LDL is acted upon by _________

Answer 17

hepatic lipase

Question 18

exclusive apolipoprotein is Apo __________

Answer 18

Apo B-100

Question 19

in LDL Receptor Mediated Endocytosis

the complex invaginated to form an __________

Answer 19

endosome

Question 20

HDL is synthesized from ____ and ____

Answer 20

liver and small intestine

Question 21

HDL begins as a Apolipoprotein _______

Answer 21

Apo A-1

Question 22

Normal value of HDL for men and women

Answer 22

40-50 mg/dL for men
50-60 mg/dl for women