Solvevt Induced Diseases

Question 0

Benzene

Answer 0

Except neuropathies,
Bone marrow depressant
Aplastic anemia
Pancytopenia

Question 1

N-hexane & methyl n-butylketone

Answer 1

Peripheral neuropathy

Question 2

Toluene

Answer 2

Except encephalopathy, Renal tubular acidosis

Question 3

Methylene chloride

Answer 3

Acute MI
Methylene chloride is a paint stripper, after inhalation, it metabolized to CO, lead to CO poisoning and MI
Increase blood Hb-CO

Question 4

Carbon tetrachloride

Answer 4

Myocardial sensitization

Question 5

Methyl bromide

Answer 5

Ataxia, seizures

Question 6

Chronic low level of organic solvent exposure can cause “ painter’s syndrome”, with Sx of ?

Answer 6

HA, dizziness, asthenia, mood and personality change, inattentiveness, forgetfulness, and depression

Question 7

Sx of Organic solvent exposure ?

Answer 7

Possible acute narcotizing (eg. Inhalated anesthetics)
Acute: brief, intense exposure = reversible encephalopathy
Chronic moderate exposure = dementing syndrome
Chronic low level exposure = “Painter’s Syndrome “
Sensorimotor polyneuropathy may also occur

Question 8

Painter’s syndrome?

Answer 8

Caused by solvents

• depression
• retarded psychomotor performance
• personality change
• decrease in short memory

Question 9

Bone marrow depressant:
Pancytopenia
Aplastic anemia
IARC class I: strongest association with AML

Answer 9

Benzene, aromatic hydrocarbons

Question 10

Chloracne at head, neck and trunk

Answer 10

PCB (poly chlorinated biphenyls )

Question 11

Scrotal cancer in chimney sweepers

Answer 11

PAH

• 3 or more benzene rings fused
• Heavy in smoked meat
• carcinogen (lung, skin, bladder and kidney)

Question 12

Antidote for Hydrofluoric acid

Answer 12

2.5% Calcium gluconate gel

Question 13

Trigeminal neuralgia

Answer 13

Trichloroethylene (TCE)

Question 14

Metabolized to carbon monoxide

Answer 14

Methylene chloride

Question 15

Athrogenic

Answer 15

Carbon disulfide

Question 16

Liver toxicity

Answer 16

Chlorinated hydrocarbons:

• carbon tetrachloride
• TCE ( trichloroethylene )
• Perchloroethylene

Question 17

Hepatic angiosarcoma

Acro-osteolysis

Answer 17

Vinyl chloride

Question 18

Magnense refiner with tremor

Answer 18

Parkinsonism

Question 19

Solvent caused neuropathy

vs metal caused neuropathy

Answer 19

Demyelinating in solvent

Axonal change in metals

Question 20

Demyelinating solvent?

Answer 20

N-hexane
Methyl-n-butyl ketone 
Carbon disulfide
Acrylamide
Trichloroethylene

Question 21

Sudden death after exposure to high levels of industrial solvents involving fluorocarbon ) freons in refrigerator mechanics), the probable mechanism?

Answer 21

Cardiac arrhythmia or simple asphyxiation.

Question 22

Degreaser’s flush

Answer 22

Trichloroethylene