Hepatitis B Flashcards

0
Q

Why is HBcAg not routinely detected?

A

Because HBcAg is sequestered within an HBsAg coat.

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1
Q

Currently available lab test for Hep B?

A
HBsAg
Anti-HBs
IgM anti-HBc
IgG anti-HBc
HBeAg
Anti-HBe
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2
Q

Which Hep B lab test is most helpful in determining whether the pt is in the acute phase of viral hepatitis?

A

IgM anti-HBc is a marker for acute (less than 6 months ) hepatitis

  1. It appears soon after the onset of infection and the detection of HBsAg.
  2. It precedes by many weeks detectable levels of anti-HBsAg.
  3. It generally disappears after 6-8 months.
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3
Q

Which lab market indicate infectivity for Hep B?

A

HBeAg

It may persist for years in pt with chronic disease and is associated with high infectivity.

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4
Q

Which marker indicates chronicity of Hep B?

A
  1. HBsAg remains detectable beyond 6 months in chronic hepatitis.
  2. HBeAg may persist for years in pt with chronic disease.
  3. Persistent elevated ALT.
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5
Q

The relationship of Age of infection of Hep B and the risk of become chronically infected?

A

The likelihood of becoming chronically infected with hepatitis B is inversely related to the age at which the infection occurs.

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6
Q

What percent of Infants born to HBsAg-positive mothers will become Hep B carrier?

A

Up to 90%

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7
Q

What percent of children infected Hep B before the age of 5 will become Hep B carrier?

A

Between 25-50%

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8
Q

What percent of acutely Hep B Infected adults will become chronically infected?

A

6-10%

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9
Q

Transmission of HBV in the US?

A
  • most HBV in fiction in the US with known routes of transmission result from sexual contact.
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10
Q

Hepatitis D virus

A
  1. A defective virus
  2. Co-infection with HBV is necessary for the replication and clinical expression of HDV
  3. Preventing hepatitis B through vaccination with HBV vaccine will protect against hepatitis D
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11
Q

Risk of seroconversion due to sharps injury from a known positive source?

A

HBV—-6-30% if not vaccinated
HCV—-~2%
HIV—-0.3%

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