Neurotoxicants

Question 0

Painter’s syndrome?

Answer 0

Long term exposure to solvent, c/o vague cognitive difficulty, particularly on memory, also on mode and affect.

Question 1

Agents that cause chronic encephalopathy including?

Answer 1

Lead
Arsenic
Manganese 
Mercury
Solvents (painter's syndrome)
Organophosphate 

(LAMs & SO)

Question 2

4 mentals that cause peripheral neuropathies are?

Answer 2

Lead
Arsenic
Mercury
Thallium

(LAM T)

Question 3

Central neurotoxicants

Answer 3

Carbon disulfide
Chlorinated hydrocarbons
CO
Metals - arsenic, lead (epilepsy), manganese (Parkinson’s), mercury
Solvents - benzene, halothane, methylene chloride, perchloroethylene (PERC), styrene, toluene, trichloroethylene (TCE)

Question 4

N-hexane & methyl n-butylketone, can cause what neuro disorder?

Answer 4

Peripheral neuropathy

N-hexane used in rubber industry
(Methyl n-butylketone used for paint)

Question 5

Toluene can cause what neuro disorder?

Answer 5

Encephalopathy

Toluene use in glue sniffer

Question 6

Cobalt & manganese impact what part of the brain?

Answer 6

Basal ganglia

Parkinson’s-like Sx

Question 7

Causes of Parkinsonism

Answer 7

Carbon disulfide
Carbon monoxide
Manganese
N-methyl-4-phenyltetrahydropyridine (MPTP) ( use in rat to create Parkinson’s animal model)

(Big 4)

Question 8

Central neurotoxicants ?

Answer 8

Carbon disulfide 
Chlorinated hydrocarbons
Carbon monoxide 
Metals - 
   Lead (epilepsy)
   arsenic
   mercury
   manganese (Parkinson's )
Solvents - 
   benzene
   halothane
   Methylene chloride
   Perchloroethylene (PERC)
   Styrene
   Toluene 
   Trichloroethylene (TCE)

Question 9

Agent that causes peripheral neuropathies?

Answer 9

Metals:
   Lead
   Arsenic
   Mercury
   Thallium
Organophosphate & carbamate pesticides
Acrylamide monomer
Carbon disulfide

Question 10

Affecting trigeminal N

Answer 10

Trichloroethylene