Sketchy - Vancomycin Flashcards
Spectrum: Vancomycin
Gram pos is Staph/Strep;
Enterococcus species
What is one of the most important indications for Vancomycin?
Blood stream infections of MRSA; HAP due to MRSA
Is Vancomycin bateriocidal or bacteriostatic?
Bacteriocidal
Do beta-lactamases affect Vancomycin?
No
What is the first line treatment for MRSA Osteomyelitis?
Vancomycin, because it penetrates well into bone
What is a good option for treating Staph epidermidis, responsible for biolfims on heart valves and IV lines?
Vancomycin
What is the first line treatment for endocarditis?
Vancomycin
What confers resistance to Vancomycin?
Altered peptidoglycan structure D-ala-D-lac
What is the first-line treatment for C. diff infection?
Metronidazole
Use oral vancomycin next if first-line therapy is ineffective (take a van to the met)
Adverse effects: Vancomycin
Red man syndrome - histamine release
Prevent by prolonging infusion or using antihistamines;
Thrombophlebitis at the injection site;
Ototoxicity and Nephrotoxicity when used with other ototixic or nephrotoxic drugs;
DRESS syndrome
What is DRESS syndrome?
Drug reaction with eosinophilia and systemic symptoms;
Can occur with Vancomycin when administered with allopurinol, anticonvulsants or sulfonamides;
2-8 weeks post-admin reaction
MOA: Vancomycin
Binds directly to the D-ala-D-ala structure of bacterial cell wall
