Pharmacology - Antifungal Therapy - Christopher Miller Flashcards
Class: Flocuonazole
Triazole
Antifungal
Class: Itraconazole
Triazole
Antifungal
Class: Voriconazole
Triazole
Antifungal
Class: Posaconazole
Traizole
Antifungal
Class: Amphotericin B
Polyene macrolide
Antifungal
Class: Nystatin
Polyene macrolide
Antifungal
Class: Caspofungin
Echinocandin
Antifungal
Class: Micafungin
Echinocandin
Antifungal
Class: Anidulafungin
Echinocandin
Antifungal
Use: Nystatin
Skin infections - Candida
Usually topical preparations
MOA: Triazoles
Impede ergosterol synthesis through direct inhibition of the cytochrome P450 dependent enzyme 14-alpha-sterol-demethylase.
Ergosterol is an essential molecule of the fungal cell membrane. Inhibition of this stops fungal growth.
Spectrum: Flunazole
Some candida;
Cryptococcus;
Endemic Mycoses (ie Histoplasmosis, Coccidiomycosis)
Spectrum: Voriconazole, Itraconazole
Fluconazole spectrum PLUS
Aspergillus, broader Candida coverage
Spectrum: Posaconazole
Voriconazole, Itraconazole spectrum PLUS Fusarium, Mucorales
Adverse effects: Triazoles
Liver enzyme abnormalities
GI side effects