Sketchy - Tetracyclines Flashcards
MOA: Tetracyclines
Bind reversibly to the 30S ribosomal subunit and interfere with bacterial protein synthesis;
Bacteriostatic;
Broad spectrum
Class: Minocycline
Tetracycline
What is first line treatment for rickettsial species?
Tetracyclines namely Doxycycline Francisella --> tuleremia Borrelia --> Lyme disease Erlichia --> Erlichiosis Rickettsia --> RMSF
What is first line treatment for zoonoses such as Brucellosis, Yersinia and Coxiella?
Doxycycline
Coxiella - Q fever, endocarditis
1 week treatment with what is effective for Chlamydia urethritis and cervicitis?
Doxycycline
When PID is suspected, Doxy os a cephalosporin are good
CAP due to atypical bugs such as chlamydia and mycoplasma are effectively treated with:
Doxycycline
Tetracycline absorption is decreased with calcium, iron and magnesium because
They chelate them (or any multivalent cation)
Why are tetracyclines not recommended for children under 8?
They chelate calcium and discolor developing teeth;
Same goes for fetal teeth and bone - do not administer tetracyclines to pregnant women
Side effects: Tetracyclines
Nausea
Vomiting
Diarrhea;
Skin photosensitivity
Administration of expired tetracylcines can cause
Fanconi syndrome, a type 2 renal tubular acidosis
What are common methods of resisting tetracyclines?
Efflux pumps;
Altered ribosomes
Do tetracyclines require dose adjustment for renal failure patients?
No, they are eliminated fecally
