Sketchy - Monobactams and Carbapenems

Question 1

Class: Monobactams

Answer 1

Beta-lactams

Question 2

Class: Carbapenems

Answer 2

Beta-lactams

Question 3

Class: Aztreonam

Answer 3

Monobactam

Question 4

Spectrum: Monobactams is Aztreonam

Answer 4

Aerobic Gram neg rods ONLY

**Pseudomonas coverage

Question 5

Types of infections covered by Aztreonam

Answer 5

Serious systemic infections with gram negative pathogens - ie meningitis, pneumonia, sepsis

Question 6

T/F: People with a penicillin allergey can be safely treated with Aztreonam

Answer 6

True, no cross-recativity

Question 7

Monobactams are resistant to:

Answer 7

Beta-lactamases

Question 8

Class: Imipenem

Answer 8

Carbapenems

Question 9

Class: Ertapenem

Answer 9

Carbapenems

Question 10

Class: Meropenem

Answer 10

Carbapenems

Question 11

Class: Doripenem

Answer 11

Carbapenems

Question 12

Spectrum: Carbapenems

Answer 12

Broad Spectrum
Gram pos;
Anaerobes (aspiration pneumonia, intra-abdominal infection);
Gram neg rods including Pseudomonas

Question 13

Are Carbapenems appropriate for empirically treating sepsis?

Answer 13

Yes - big gun! good for HAP and sepsis, meningitis and resistant bugs

Question 14

What is unique about Imipenem?

Answer 14

It is inactivated in the renal tubule and must be administered with cilastin to avoid inactivation

Question 15

Adverse effects: Carbapenems but mostly Imipenem

Answer 15

GI - Nausea and diarrhea;
Rash;
Imipenem lowers the seizure threshold in patients with renal dysfx

Question 16

What is you best treatment option for extended spectrum beta-lactamases such as E. Coli and Klebsiella?

Answer 16

Carbapenems