Microbiology - Enteric viruses I & II - Rebecca Greenblatt Flashcards
Reoviruses have a segmented genome, which has what mode of gaining genetic diversity?
Reassortment
Transmission: Rotavirus (reovirus)
fecal-oral
Orthoreoviruses cause:
Mild GI symptoms
Rotavirus causes severe:
dehydration, even though diarrhea is self-limited
What cells does rotavirus act on?
The cells of the small intestinal villi
What does rotavirus have that acts like an enterotoxin?
NSP4 - rotavirus nonstructural protein 4 - interferes with sodium transport pumps - profuse watery diarrhea
Phylogeny: Rotavirus
ds RNA virus
+ sense
icosahedral
naked
Phylogeny: Norovirus
ss RNA virus
- sense
icosahedral
naked
Transmission: Norwalk virus (norovirus)
fecal-oral
IU: Norwalk virus
low
IU: Rotavirus
high
Pathogenesis: Norovirus
Infection damages microvilli in small intestine → malabsorption
Vomiting is more common in what enterovirus?
Norovirus - slows gastric emptying as comparing with rotavirus
What is primary viremia?
Successful virus travels in blood to seed replication site(s). LOW LEVELS in blood.
What is secondary viremia?
New virus travels from replication site(s) to shedding site(s). HIGHER LEVELS in blood.
Phylogeny: Picornaviruses ie Poliovirus, Hep A, Coxsackievirus
Small naked icosahedral \+ sense ss RNA