Sketchy - Cell Wall and Membrane Active Antibiotics - Nafcillin/Oxacillin/Dicloxacillin

Question 1

What structures do Oxacillin/Nafcillin/Dicloxacillin have to prevent the effects of beta-lactamase?

Answer 1

Bulky R group on beta lactam ring

Question 2

What are Oxacillin/Nafcillin/Dicloxacillin best used for?

Answer 2

Methicillin-sensitive but penicillin-resistant strains of Staph

Mild to moderate localized staph infections

Question 3

What is an appropriate treatment for STTIs such as folliculitis and abscesses?

Answer 3

Oxacillin/Nafcillin/Dicloxacillin

Naf for staph

Question 4

Staph endocarditis and Staph osteomyelitis may be treated with IV _______.

Answer 4

Oxacillin/Nafcillin/Dicloxacillin

Question 5

The adverse effects of Oxacillin/Nafcillin/Dicloxacillin are similar to the penicillins and include:

Answer 5

Hypersensitivity reactions;

Interstitial nephritis

Question 6

How does MRSA resist penicillins and Oxacillin/Nafcillin/Dicloxacillin ?

Answer 6

MRSA makes altered PBPs that have low affinity for beta-lactams

Question 7

Class: Oxacillin/Nafcillin/Dicloxacillin

Answer 7

Penicillinase-resistant penicillins

Question 8

Adverse effects:

Oxacillin/Nafcillin/Dicloxacillin

Answer 8

Hepatotoxicity & neutropenia w/ oxacillin; neutropenia & thrombophlebitis w/ nafcillin