Rubin's 21: Pancreas

Question 1

Injury to what cells results in acute pancreatitis?

Answer 1

Acinar cells

Question 2

Dx: Late complication of acute pancreatitis; Necrotic pancreatic tissue is liquefied through the action of pancreatic enzymes; Tissue then becomes encapsulated by granulation tissue

Answer 2

Pancreatic pseudocyst Persistent abdominal pain Anorexia Abdominal distention

Question 3

Dx: Migratory thrombophlebitis

Answer 3

Trousseau syndrome May accompany adenocarcinoma of the pancreas (as well as other malignancies)

Question 4

The majority of pancreatic carcinomas arise from what cell type?

Answer 4

Ductal cells

Question 5

Painless jaundice is a frequent initial symptom of:

Answer 5

Pancreatic cancer

Question 6

Dx: Intractable gastric hypersecretion; Severe peptic ulceration of the duodenum and sometimes jejunum; Elevated gastrin levels

Answer 6

Zollinger-Ellison syndrome tumor responsible is pancreatic gastrinoma made of G cells

Question 7

Dx: Necrotizing migratory erythema; Mild hyperglycemia and anemia

Answer 7

Glucagonoma Hypersecretion of glucacon by alpha cell tumors

Question 8

Dx: Mild DM syndrome; Foul-smelling stool; Steatorrhea; Gallstones; Hypochlorhydia

Answer 8

Delta cell tumor - pancreas

Question 9

Dx: Adenoma of pituitary leading to acromegaly; Hyperplasia of parathyroids leading to hypercalcemia; Adenoma of exocrine pancreas (gastrinoma)

Answer 9

MEN type 1 Can result in Z-E syndrome Mutations in MEN1 tumor suppressor gene