Sketchy - Daptomycin Flashcards
1
Q
Spectrum: Daptomycin
A
Gram pos - Staph, Strep, Enterococcus
2
Q
MOA: Daptomycin
A
Inserts tail into bacterial cell wall –> depolarization of cell and death
Bacteriocidal
3
Q
When is daptomycin used?
A
When there is resistance to vancomycin ie Enterococcus (UTI, GI) and vanco-resistant MRSA
4
Q
Staph endocarditis is effectively treated with Vanco or:
A
Daptomycin
5
Q
Why is Daptomycin not recommended for treating pneumonia?
A
It is antagonized by pulmonary surfactant
6
Q
Adverse effects: Daptomycin
A
Myopathy, rhabdomyolysis
Monitor Creatinine phosphokinase levels
