Pharmacology - Antiviral Therapy I and II Flashcards
Class: Acyclovir; Penciclovir
Purine analog (guanosine)
Class: Valacyclovir; Famciclovir
Purine analog (guanosine)
MOA: Valacyclovir; Famciclovir
Prodrug converted to Acyclovir & Penciclovir,respectively –> After phosphorylation, causes viral DNA chain termination
MOA: Acyclovir; Penciclovir
After phosphorylation, causes viral DNA chain termination
Class: Ganciclovir
Purine analog (guanine)
MOA: Ganciclovir
After phosphorylation, causes viral DNA chain termination
Class: Foscarnet
Pyrophosphate congener
MOA: Foscarnet
Directly inhibits HSV DNA polymerase or HIV reverse transcriptase
Use: Foscarnet
Broad spectrum (HSV/VZV/CMV, and RNA viruses including HIV)
use for resistant strains only due to toxicity concerns
Use: Ganciclovir
Treatment & prophylaxis of CMV infection (but also HSV, VZV)
**Valganciclovir for PO bc of much higher bioavailabiltiy
Use: Valacyclovir; Famciclovir;
Acyclovir; Penciclovir
HSV, VZV (requires higher dose than HSV)
Side effects: Valacyclovir; Famciclovir;
Acyclovir; Penciclovir
CNS changes and renal dysfunction possible when used at higher doses
Side effects: Ganciclovir
Neutropenia, thrombocytopenia
Side effects: Foscarnet
Dose-dependent renal and CNS toxicities, electrolyte & metabolic abnormalities;
Myelosuppression
What specific scenario is Foscarnet recommended for?
Used for invasive HSV/VZV infections from acyclovir resistant strains; alternative to ganciclovir for CMV
Side effects: Tenofovir
Nephrotoxicity;
Lactic acidosis;
GI issues
Side effects: Abacavir
Hypersensitivity reaction;
Lactic acidosis;
GI issues
Side effects: Zidovudine
Anemia;
Granulocytopenia
Lactic acidosis;
GI issues
Class: Zidovudine
NRTI
Class: Lamivudine (Epivir); Emtricitabine (Emtriva)
NRTI
Class: Tenofovir
NRTI
Class: Abacavir
NRTI
Class:
Efavirenz (Sustiva);
Nevirapine (Viramune); Rilpivirine (Edurant);
Etravirine (Intelence)
NNRTI
MOA: NRTIs Zidovudine; Lamivudine; Emtricitabine; Tenofovir; Abacavir
Inhibits reverse transcriptase
Use: Abacavir, Zidovudine
HIV
Use: Lamivudine, Emtricitabine, Tenofovir
HIV and HBV
Side effects: Lamivudine (Epivir); Emtricitabine (Emtriva)
Headache; N & V; rash; neutropenia; pancreatitis
Side effects: Efavirenz
• CNS symptoms!!
-vivid dreams
-drowsiness
• Teratogenic
Side effects: Nevirapine
Rash;
Hepatitis including hepatic necrosis
Side effects: Etravirine
Rash;
Increased LFTs
Side effects: Rilpivirine
Rash;
QT prolongation
Class: Efavirene;
Nevirapine;
Rilpivirine;
Etravirine
NNRTIs
MOA: NNRTIs Efavirene; Nevirapine; Rilpivirine; Etravirine
Inhibit reverse transcriptase through direct enzyme inhibition instead of a nucleoside base