Skeletal Muscle Physiology 2 Flashcards

Dr S Khogali

1
Q

skeletal muscle tension is dependant on 2 factors. what are they?

A

number of muscle fibres contracting and tension developed by each fibre

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2
Q

in skeletal muscle, the duration of twitch is much shorter than the duration of reaction potential

true or false?

A

false

the duration of action potential is much shorter than the duration of resulting twitch

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3
Q

what is evoked when the motor nerve that innervates a skeletal muscle emits action potentials at a very high rate?

A

tetanus

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4
Q

what muscle type cannot be tetanised?

A

cardiac muscle due to refractory period

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5
Q

what is produced if skeletal muscle is stimulated once?

A

a twitch

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6
Q

The tension developed by skeletal muscle increases with increasing frequency of stimulation

true or false?

A

true

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7
Q

Maximal tetanic contraction can be achieved when the muscle is at its _______ ______ before the onset of contraction

A

optimal length

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8
Q

name the 2 types of muscle contraction

A

isotonic contraction

isometric contraction

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9
Q

what is isotonic contraction used for?

A

body movements and moving objects

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10
Q

what is isometric contraction used for?

A

supporting objects in fixed position and posture

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11
Q

in which type of contraction does the muscle length change?

A

isotonic contraction

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12
Q

outline 3 ways metabolic pathways supply ATP in muscle fibre

A

from creatine
oxidative phosphorylation
glycolysis

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13
Q

when do we get ATP from glycolysis?

A

when O2 is not present

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14
Q

name the 3 types of muscle fibres

A

type I
type IIa
type IIx

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15
Q

what are type I fibres aka?

A

slow oxidative

slow twitch

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16
Q

what are type IIa fibres aka?

A

fast oxidative

intermediate twitch fibres

17
Q

what are type IIx fibres aka?

A

fast glycolytic

fast twitch

18
Q

list what each muscle fibre is used for

A

type I - low work aerobic
type IIa - moderate work
type IIx - short term high intensity

19
Q

what is the simplest monosynaptic spinal reflex?

A

stretch reflex

20
Q

what feedback is seen in the stretch reflex?

A

negative feedback

21
Q

stretching the muscle spindle increases firing in which type of neurone?

A

afferent neurone

22
Q

what is another name for muscle spindles?

A

intramural fibres

ordinary muscle is extrafusal fibres

23
Q

what are annulospiral fibres?

A

the sensory endings to muscle spindles

24
Q

what are the efferent neurones that supply muscle spindles called?

A

gamma motor neurones

25
Q

name some genetically determined myopathies

A

muscular dystrophy

myotonia

26
Q

name an acquired inflammatory myopathy

A

polymyositis

27
Q

name an acquired non-inflammatory myopathy

A

fibromyalgia

28
Q

name an endocrine myopathy

A

Cushing syndrome

29
Q

list some useful investigations in neuromuscular disease

A

ECG
enzymes - CK
inflammatory markers - CRP and PV
muscle biopsy

30
Q

whats the fastest way to a mans heart if your clara white?

A

through his ribcage