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Musculoskeletal > Immunology of Autoimmune Diseases > Flashcards

Immunology of Autoimmune Diseases Flashcards

Dr S Matthews

1
Q

what antibody is associated with type II and III hypersensitivity reactions?

A

IgG

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2
Q

what antibody is found at mucosal surfaces?

A

IgA

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3
Q

name the 2 different types of immune response

A

innate

acquired

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4
Q

in which response is there no immunological memory?

A

innate

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5
Q

which response is non-specific?

A

innate

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6
Q

which response is associated with regulatory T cells?

A

acquired

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7
Q

which response has memory?

A

acquired

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8
Q

which response distinguishes self from non-self?

A

acquired

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9
Q

what is another name for T Helper cells?

A

CD4+ T cells

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10
Q

what is another name for CD8+ T cells?

A

cytotoxic T-cells

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11
Q

what are CD4+ T cells associated with?

A

MHC class II cells

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12
Q

what are MHC class 2 cells present on?

A

Antigen-pressenting cells

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13
Q

what are CD8+ T cells associated with?

A

MHC class I cells

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14
Q

where are MHC class I cells present?

A

all cells of body

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15
Q

what gene mutation is important in IPEX syndrome?

A

FOXP3 gene

HLA (MHC) genes important too

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16
Q

Goodpasture syndrome is a type of what hypersensitivity reaction?

A

type II

17
Q

SystemicLupus Erythmatosus is a type of what hypersensitivity reaction?

A

type III

18
Q

what antibodies are seen in type II reactions?

A

IgG and IgM

19
Q

what are type II reactions mediated by?

A

cell-mediated immune complexes

20
Q

what type of reaction is TB?

A

type IV

21
Q

what is type IV reactions mediated by?

A

T cells

22
Q

what auto-antibody is important in MG?

A

auto-IgG

23
Q

in MG, what are CD4+ T cells activated by?

A

unfolded AChR subunits

24
Q

what are unfolded AChR subunits expressed by?

A

thymic epitelial cells

25
Q

what do effector TH cells stimulate auto-reactive B cells to produce in MG?

A

AChR antibodies

26
Q

what do AChR antibodies attack?

A

thymic thyoid cells

27
Q

what do thymic thyoid cells release in response to attack?

A

AChR-immune complexes

28
Q

what do AChR-immune complexes

activate to further the response?

A

other APCs

29
Q

These AChR antibodies block binding of what? leading to defects in nerve impulse transmission at the NMJ.

A

endogenous ACh to the receptors

30
Q

what is the treatment of MG to increase neurotransmission?

A

anti-cholinesterase agents

31
Q

what is the treatment of MG to reduce autoimmunity?

A

methotrexate, azathioprine and corticosteroids

IV IgG

32
Q

name the new terminal pathway complement inhibitor drug for MG

A

Eculizumab

33
Q

what is the surgery in the treatment of MG called?

A

thymectomy

34
Q

what type of response is seen in RA?

A

Type IV

HLA-DR4, is the major susceptibility haplotype in most ethnic groups

35
Q

what type of reaction is MG?

A

type II reaction

Musculoskeletal (37 decks)

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