Immunology of Autoimmune Diseases

Question 1

what antibody is associated with type II and III hypersensitivity reactions?

Answer 1

IgG

Question 2

what antibody is found at mucosal surfaces?

Answer 2

IgA

Question 3

name the 2 different types of immune response

Answer 3

innate

acquired

Question 4

in which response is there no immunological memory?

Answer 4

innate

Question 5

which response is non-specific?

Answer 5

innate

Question 6

which response is associated with regulatory T cells?

Answer 6

acquired

Question 7

which response has memory?

Answer 7

acquired

Question 8

which response distinguishes self from non-self?

Answer 8

acquired

Question 9

what is another name for T Helper cells?

Answer 9

CD4+ T cells

Question 10

what is another name for CD8+ T cells?

Answer 10

cytotoxic T-cells

Question 11

what are CD4+ T cells associated with?

Answer 11

MHC class II cells

Question 12

what are MHC class 2 cells present on?

Answer 12

Antigen-pressenting cells

Question 13

what are CD8+ T cells associated with?

Answer 13

MHC class I cells

Question 14

where are MHC class I cells present?

Answer 14

all cells of body

Question 15

what gene mutation is important in IPEX syndrome?

Answer 15

FOXP3 gene

HLA (MHC) genes important too

Question 16

Goodpasture syndrome is a type of what hypersensitivity reaction?

Answer 16

type II

Question 17

SystemicLupus Erythmatosus is a type of what hypersensitivity reaction?

Answer 17

type III

Question 18

what antibodies are seen in type II reactions?

Answer 18

IgG and IgM

Question 19

what are type II reactions mediated by?

Answer 19

cell-mediated immune complexes

Question 20

what type of reaction is TB?

Answer 20

type IV

Question 21

what is type IV reactions mediated by?

Answer 21

T cells

Question 22

what auto-antibody is important in MG?

Answer 22

auto-IgG

Question 23

in MG, what are CD4+ T cells activated by?

Answer 23

unfolded AChR subunits

Question 24

what are unfolded AChR subunits expressed by?

Answer 24

thymic epitelial cells

Question 25

what do effector TH cells stimulate auto-reactive B cells to produce in MG?

Answer 25

AChR antibodies

Question 26

what do AChR antibodies attack?

Answer 26

thymic thyoid cells

Question 27

what do thymic thyoid cells release in response to attack?

Answer 27

AChR-immune complexes

Question 28

what do AChR-immune complexes | activate to further the response?

Answer 28

other APCs

Question 29

These AChR antibodies block binding of what? leading to defects in nerve impulse transmission at the NMJ.

Answer 29

endogenous ACh to the receptors

Question 30

what is the treatment of MG to increase neurotransmission?

Answer 30

anti-cholinesterase agents

Question 31

what is the treatment of MG to reduce autoimmunity?

Answer 31

methotrexate, azathioprine and corticosteroids IV IgG

Question 32

name the new terminal pathway complement inhibitor drug for MG

Answer 32

Eculizumab

Question 33

what is the surgery in the treatment of MG called?

Answer 33

thymectomy

Question 34

what type of response is seen in RA?

Answer 34

Type IV HLA-DR4, is the major susceptibility haplotype in most ethnic groups

Question 35

what type of reaction is MG?

Answer 35

type II reaction