MSK Microbiology Flashcards
Dr B Mooka
what drug is used to treat staph aureus?
Flucloxacillin
what is the side effect in the use of clindamycin?
C. diff
where is adult osteomyelitis likely to occur?
long bone medullary cavity
how do you class osteomyelitis?
by time
acute vs. chronic
name the treatment approach to infection
debridement
antimicrobials
if you can see bone, see tendon and infection, what is the diagnosis?
osteomyelitis
osteomyelitis is a medical emergency.
true or false?
false
only if sepsis too
you must start empiric antibiotics immediately in chronic osteomyelitis.
true or false?
false*
you can afford to wait a few days
how long does debrided tissue take to be covered by soft tissue?
6 weeks
how long is the treatment in osteomyelitis?
6 weeks
coagulase negative staph only really cause problems in those with prosthetics
true or false?
true
coagulase negative staph only virulent in presence of plastic and metal
name examples of osteomyelitis
open fractures diabetes/vascular insufficiency haematogeneous osteomyelitis vertebral osteomyelitis ***
describe staph aureus
common coagulase positive gram positive clusters produce enzymes ***
what is the clue in open fracture infection?
poor wound healing
in diabetes/venous insufficiency, what is the common pathogen?
often polymicrobial but staph aureus is most common
in diabetes/venous insufficiency, what is the treatment?
debridement and antimicrobials
what is the way to tell you what the infection is? best test?
bone biopsy
what drugs do you use for gram negatives?
gentamycin*
what is the alternative to flucloxacillin for people with a penicillin allergy?
vancomycin
name the duration of treatment in diabetic foot infection.
mild - 7days*
moderate - 7days*
severe - 7days*
osteomyelitis - 6 weeks*
what drugs do you use for anaerobes?
metronidazole*
name the drug and allergy alternative and oral switch for gram positive cover.
Flucloxacillin IV
vancomycin if allergic
oral switch - doxycycline
what drug is no use systemically?
vancomycin
topical treatment for bowel i.e. gastroenteritis
who are the likely people to have haematogenous osteomyelitis?
prepubertal children
PWID
elderly