Signaling and RTKs Flashcards
Give an example of a lipophilic (hydrophobic) hormone.
Steroid hormones
Gefitinib blocks _____ and thus stops downstream signaling.
EGFR kinase activity
Give an example of a hydrophilic (lipophobic) hormone.
proteins/peptides/amino acids
____ is likely the most extensive node in signaling.
Ca2+
Most ______ target signaling molecules.
non-antibiotic drugs
Two major classes of signaling molecules are ____ and ____.
lipophilic (hydrophobic) and hydrophilic (lipophobic)
____ are points in a network that receive multiple inputs and/or multiple outputs.
Nodes
_____ is the target for Sildenafil.
PDE5
PDE5 is the target for ______.
Sildenafil
Endocrine signaling
hormone is circulated in the bloodstream
What drug is an anti-EGFR that blocks the ligand binding site?
cetuximab
Ca2+ is likely the most extensive ____ in signaling.
node
____ is NOT a second messenger; its signaling is not concentration dependent.
GTP
_____ blocks EGFR kinase activity and thus stops downstream signaling.
Gefitinib
Most non-antibiotic drugs target ______.
signaling molecules
Contact-dependent signaling
the mediator is membrane-bound
Autocrine signaling
the receptor is on the same cell that sent the signal
Nodes are points in a network that _____.
receive multiple inputs and/or multiple outputs
_____ are groups of components (or building blocks) that function together.
Modules
Synaptic signaling
neurons use neurotransmitters to signal nearby cells
______ are membrane-bound switches that are regulated by GAPs and GEFs
Ras proteins
cetuximab
anti-EGFR that blocks the ligand binding site
Ras proteins are membrane-bound switches that are regulated by ____ and ____.
GAPs; GEFs
Modules are groups of components (or building blocks) that _____.
function together
Paracrine signaling
target cells are nearby
