Cytoskeleton II Flashcards
What binds to and stabilizes F-actin?
phalloidin
The formation and contraction of the actomyosin ring drives the ____ and _____.
cleavage furrow; separation of daughter cells
phalloidin
from death cap, binds to and stabilizes F-actin
Activation of forming leads to _____ formation.
parallel actin bundle
Myosin II, characteristic of _____, forms hetero-oligomers involving two heavy chains and two copies of each of two light chains.
striated muscle
Lissencephaly
defect of brain development- no gyri- loss of n-cofilin
_____ are filamentous polymers (~7 nm diameter) of actin monomers.
Microfilaments
WASp
Wiskott-Aldrich syndrome protein
_____ is observed in microvilli inclusion disease.
Loss of microvilli
Rho activation causes the formation of ____ and ____.
stress fibers and focal adhesions
In the presence of divalent cations and ATP, ____ assembles to form two stranded, helical filaments called ____.
G-actin; F-actin
Activation of _____ leads to parallel actin bundle formation.
forming
Myosin II, characteristic of striated muscle, forms hetero-oligomers involving ____ and two copies of each of ____.
two heavy chains; two light chains
_____ are held together by the cross-linking proteins villin and fimbrin.
Actin bundles
_____ are essential for amoeboid motility and muscle contraction.
Microfilaments
_____ are critical for cell shape, movement, and polarity.
Microfilaments (MFs)
N-cofilin is an ____.
actin filament depolymerizing factor
____ stimulates Arp2/3 complexes.
WASp
The formation and contraction of the ____ drives the cleavage furrow and separation of daughter cells.
actomyosin ring
Microfilaments are essential for ______ and _____.
amoeboid motility; muscle contraction
____ causes the formation of stress fibers and focal adhesions.
Rho activation
Actin bundles are held together by the cross-linking proteins ____ and _____.
villin; fimbrin
___ activates the formation of veils.
Rac
____ activates the protrusion of fillopodia.
Cdc42
