MS Flashcards
In MS, the speed of transmission is _____.
decreased
In MS, the latency is _____.
prolonged
What does Dalfampridine do?
blocks K+ channels and improves walking speed
Demyelination causes proliferation of _____ along the axons.
sodium channels
______ causes proliferation of sodium channels along the axons.
Demyelination
What is molecular mimicry?
different antigens may cause the same immune reaction if they are similar to each other
In MS, the ______ is prolonged.
latency
In MS, the amplitude of response is ______.
smaller
If you see contrast in the brain, you should think that ______.
the blood brain barrier has been disrupted
In MS, the _____ is decreased.
speed of transmission
Dawson’s fingers
demyelination of the brain around the lateral ventricles causing distinct finger-like projections on imaging
What most often causes decreased quality of life in MS?
pain
The ____ MS is treated, the _____ the outcomes.
earlier; better
MS is _______ and ________.
progressive; degenerative
Genes related to MS do not cause the disease- they ______.
increase the susceptibility to getting MS
What does flecainide do?
it’s a sodium channel blocker to preserve axons
What is the main underlying cause of MS?
demyelination
What is the lifetime risk for a Colorado resident with a first degree affected relative to get MS?
3%
What are the common symptoms of MS?
fatigue, walking impairment, spasticity, cognitive impairment, bladder dysfunction, pain, mood instability, sexual dysfunction
With ________ sodium entry into the cell, impulse conduction is slowed.
increased
How many lesions occur if no treatment is given?
about 5 per
In MS, the _______ of response is smaller.
amplitude
Name 2 drugs given to block sodium channels and preserve axons.
phenytoin and flecainide
Why does calcium-mediated nerve injury occur in demyelination?
the sodium-calcium exchange is reversed and calcium influxes into the cell
