Cholera

Question 1

Constitutive cAMP production leads to secretion of H2O, Na+, K+, Cl−, and HCO3− into the lumen of the small intestine and _____.

Answer 1

rapid dehydration

Question 2

The cholera toxin (CTX or CT) is an oligomeric complex made up of ___ protein subunits.

Answer 2

6

Question 3

The _____ is an oligomeric complex made up of six protein subunits.

Answer 3

cholera toxin (CTX or CT)

Question 3

In cholera, the A1 subunit of CTX binds to the ____, causing constitutive production of cAMP.

Answer 3

GPCR

Question 4

In cholera, the ____ of CTX binds to the GPCR, causing constitutive production of cAMP.

Answer 4

A1 subunit

Question 5

Constitutive cAMP production leads to secretion of _____ into the lumen of the small intestine and rapid dehydration.

Answer 5

H2O, Na+, K+, Cl−, and HCO3−

Question 6

Cholera can be successfully treated with ___.

Answer 6

oral rehydration therapy (ORT)

Question 8

In cholera, the A1 subunit of CTX binds to the GPCR, causing ______ of cAMP.

Answer 8

constitutive production

Question 9

______leads to secretion of H2O, Na+, K+, Cl−, and HCO3− into the lumen of the small intestine and rapid dehydration.

Answer 9

Constitutive cAMP production