Membrane Fusion Flashcards
All cellular membranes are composed from a ____ with ____ facing the outside and interacting with ____.
lipid bilayer; charged residues; water molecules
The viral fusion domain is _____ within the viral protein.
folded and hidden
Upon receiving _______, the viral fusion domain is exposed and inserted into the target cell membrane.
a specific signal (like a change in pH),
Viral fusion proteins contain a _____ at the one end and a _____.
transmembrane domain; highly hydrophobic fusion domain
The formation of highly stable SNARE complex drives _______.
membrane fusion
____ uses _____ to generate energy needed to disassemble the SNARE complex.
NSF; ATP hydrolysis
____ and _____ disassemble the SNARE complex.
NSF; αSNAP
VAMP is located in the _________.
transport vesicle
Syntaxin and SNAP are located in ________.
the target membrane
Name 4 membrane bound organelles.
1) nucleus, 2) endosomes 3) lysosomes 4) mitochondria
What proteins help the transport vesicle to fuse with the target membrane?
SNAREs
intracellular vesicle transport
transport of proteins in and out of membrane bound organelles without compromising their identity
The _____ domain is inserted into the target cell membrane when a virus attacks.
viral fusion
Sec1 protein binds and changes ____ to refold the SNARE proteins back into the _________.
syntaxin; active conformation
Name 3 enveloped viruses.
1) HIV 2) ebola 3) influenza