Sept18 A1-Obstetrical Complications Flashcards
1
Q
charact of RBC isommunization
A
- any individual who lacks a specific RBC antigen may produce an Ab if exposed to that RBC antigen (foreign)
- maternal Abs are formed against fetal erythrocyte antigens and may cross the placenta to cause fetal red cell lysis and anemia
2
Q
on average, how much antigens fetus has on RBCs that mother doesn’t have
A
will typically inherit one antigen from the father that is lacking in the mother
3
Q
what is RBC alloimmunization (isoimmunization) in pregnancy
A
development of Abs in the mother to Ags that the fetus has and that the mother doesn’t have
4
Q
complications of RBC alloimmunization (isoimmunization) in pregnancy
A
- fetal anemia
- fetal hydrops (edema and heart failure)
- fetal death
5
Q
prevalence of RBC alloimmunization in pregnancy
A
1%
6
Q
risk of alloimmunization in pregnancy if fetus is Rh+ and mother Rh- (father Rh+ gave it to fetus)
A
16%
7
Q
most important thing to do to prevent alloimmunization in pregnancy
A
- give vaccination against the CDE system (Rh)
- contains anti-D immune globulin
