Sept17 A2-prematurity Flashcards

1
Q

prematurity def

A

born at less than 37 completed weeks

-note: threshold of viability is 22-25

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2
Q

prematurity classifications

A
  • by weight

- by gestational age

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3
Q

classif by weight

A
  • low birth weight = <2500g
  • very LBW (VLBW) = <1500g
  • extremely LBW (ELBW) = <1000g
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4
Q

classif by gestational age

A
  • extreme premature = <28 wks
  • late pre term = 34 to 36.85
  • weight AGA (appropriate for gestational age)
  • weight LGA (large for gest age): above 90th percentile
  • wieght SGA (small for gest age): below 90th percentile
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5
Q

intra uterine growth restriction def (IUGR)

A
  • NOT SGA
  • process limiting fetus from achieving full growth potential
  • either symmetric or asymmetric (head also small = symmetric. body small compared to head = asymmetric)
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6
Q

reasons for premature birth

A
  • medical risk factors

- environmental risk factors

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7
Q

medical RFs

A
  • maternal (Age, prior preterm birth, chronic illness, clotting disorder)
  • anatomical (cervical or uterine)
  • pacental
  • infection
  • fetal
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8
Q

environmental RFs

A
  • smoking
  • alcohol
  • drugs
  • poor prenatal care
  • low maternal education and SES
  • malnutrition
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9
Q

(IMP?) main risks for a premature baby in the first 24 hours

A
  • hypothermia
  • dehydration
  • respiratory distress syndrome (RDS) (thing about alveoli surfactant)
  • hypoglycemia
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10
Q

why hypothermia in premature newborns

A
  • born wet
  • cold environment
  • high surface to body volume ratio
  • insufficient brown fat stores (for thermogenesisi)
  • porous skin
  • less fat insulation
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11
Q

forms of heat loss in premature baby hypothermia

A
  • radiation (normal loss of EM radiation to colder usrroundings) = avoid cold delivery room, keep in isolette or use radiant warmer)
  • conduction: loss of heat by contact with colder object = use warm blankets, had, warm surface
  • convection = loss of heat by contact with colder air current = avoid cold drafts and keep in isolette)
  • evaporation (loss of heat by conversion of water to apor at skin surface ) = keep high humidity in the closed isolette, put infant in plastic bag if <32 weeks
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12
Q

causes of premature baby dehydration

A
  • transepidermal water loss (insensible = not measurable) bc of high surface-volume ratio and less keratinization of skin
  • resp tract (insensible)
  • urinary (sensible): immature renal fct, reduced ability to reabsorb water and Na
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13
Q

how to prevnent dehydration of premature

A
  • humidified air in isolette and when ventilate

- IV fluids for all infants under 34 wks

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14
Q

what are the signs of RDS (or HMD = hyaline membrane disease)

A
  • tachypnea (90 RR)
  • grunting (expiring against close epiglottis to increase FRC)
  • nasal flaring
  • needs 40% O2
  • see intercostal spaces
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15
Q

cause of RDS

A

relative deficiency in surfactant (produced by alveolar type 2 pneumocytes as of 24 wks, mature levels at 35). surfactant reduces surface tension in alveolar-air interface so easier to inflate alveoli

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16
Q

consequences of surfactant deficiency in RDS (what leads to sx)

A
  • reduced lung compliance (lower tidal volume, higher pCO2, tachypneic)
  • reduced FRC (atelectasis, VQ mismatch bc of atelectasis, increased O2 needs therefore. + grunting)
17
Q

definitive tx or RDS

A
  • intubate (mechanical ventilation)
  • exogenous surfactant administration
  • before this, can support with IV fluids, O2 and CPAP*
18
Q

normal glucose in the neonate

A

2.6 mmol per L and more

19
Q

sx of hypoglycemia in premature neonate

A
  • tachypnea
  • irritability
  • jitteriness
  • hypotonia
  • lethargy
  • convulsion
20
Q

causes of hypoglycemia in premature neonate

A
  • increased energy demand (resp, thermoregulation, cerebral metab)
  • reduced stores (less glycogen in muscles and liver)
  • insufficient gluconeogenesis
21
Q

what is breath holding spell

A

TERM baby stops breathing on occasion

22
Q

what is apnea of prematurity

A
  • baby stops breathing on occasion, desatures to 70% and bradycardia to 80s
  • need to stim to breathe again
23
Q

caution about apnea of prematurity

A

IS A DIAGNOSIS OF EXCLUSION

  • not always benign
  • search for other problems like hypoglycemia, sepsis that can also cause apnea before saying apnea of prematurity
24
Q

causes of apnea of prematurity

A
  • central (decreased resp drive and response to chemoreceptors)
  • obstructive (collapse of airways due to lack of pharyngeal muscle tone)
  • mix of both
25
Q

tx of apnea of prematurity

A
  • supportive (O2, stim)
  • relieve obstruction (CPAP)
  • xanthines (caffeine) to inhibit adenosine Rs and act as stim in CNS)
  • mechanical ventilation
26
Q

brain condition premature babies are at risk for

A

intraventricular hemorrhage (IVH)

27
Q

complications of IVH

A
  • hydrocephalus (CSF evacuation blocked)

- neurodevelopmental disabilities

28
Q

grading of IVH

A

grades 1 to 4

  • grade 1 = best prognosis
  • grade 4 = bleeding in parenchyma = worse prognosis
29
Q

when does survival start being very high in premature neonates (when parents can’t choose if resuscitate or not)

A

25 weeks and higher

30
Q

long term morbidities of premature babies

A
  • cerebral palsy (gross and fine motor deficits)
  • language delay or deficit
  • hearing impairment
  • visual impairment
  • cognitive deficits and difficulties at school (ADHD and learning disabilities = are minor things)
  • behavioral concerns