Aug29 M2-Synthesis_Steroid_Hormones Flashcards
(imp) adrenal cortex steroids
androgens, glucocorticoids, mineralocorticoids
(imp) ovaries steroids
progesterone, androgens, estradiol
(imp) testes steroids
testosterone, estradiol
(imp) placental steroids
all steroids
(imp) adipose tissue steroids
visceral estrone
mother molecule of corticosteroids (cortisol), androgens, estrogens
progesterone
progesterone derived from what
cholesterol
important carriers of steroids in hte body
lipoproteins (helped by apoprotein B)
(EXAM) step 1 of steroid synthesis
cytosolic cholesterol transferred in the mt by STAR PROTEIN (steroidogenic acute regulatory protein)
(EXAM) step 2 of steroid synthesis
mitochondrial cholesterol is made into pregnenolone by side chain cleavage enzyme (SCCE) DESMOLASE
(EXAM) step 3 of steroid synthesis. what happens to pregnenolone
becomes progesterone
(EXAM) step 4 of steroid synthesis
progesterone makes the 3 diff pathways.
(EXAM) pathway of progesterone to form sex hormones
- prog made into 17 alpha hydroxy prog by 17 alpha hydroxylase
- 17 ahp made into androstenedione
- androstenedione made into testo
- testo made into estradiol
(EXAM) pathway of progesterone to form cortisol (glucocorticoids)
- prog made into 17 ahp by 17 alpha hydroxylase
- 17 ahp made into 11-deoxycortisol by 21 alpha hydroxylase
- deoxycortisol made into cortisol by B1 isoform of 11 beta hydroxylase
(EXAM) pathway of progesterone to form aldosterone
- prog made into