Sept. 16, 2019 Flashcards
Local mnfts, exudates, systemic mnfts, pathogenesis of fever, CRP, Tx of inflm, Abn IR
Characteristics of LOCAL MNFTS
Present at site of INJURY (ERYTHEMA, HYPEREMIA, warmth, swelling, pain, l/o Fx
What is EXUDATE composed of?
CELLS, PROTEINS, FLUID
What factors may effect the composition of an EXUDATE?
Severity and type of INJURY
What is one major difference between PLASMA and SERUM?
PLASMA contains CLOTTING FACTORS, SERUM does not
2 characteristics of SEROUS EXUDATE
1) Clear
2) Watery
Why might SEROUS EXUDATE be more watery than other EXUDATES?
Because it contains more FLUID than CELLS and PROTEINS
Is an INJURY that produces a SEROUS EXUDATE considered mild, moderate, or severe? Explain
Mild. If the EXUDATE is SEROUS, it contains more FLUID than CELLS and PROTEINS, this occurs in a mild INJURY because there is less demand for CELLS and PROTEINS, which would include more LEUKOCYTES for repair.
2 characteristics of PURULENT/SUPPERATIVE EXUDATE
1) Cloudy
2) Foul odor
What is PURULENT EXUDATE composed of?
WBCs, PROTEINS, and NECROTIC DEBRIS
Why is PURULENT EXUDATE thicker than SEROUS?
Because the NECROTIC DEBRIS is a more solid form of FLUID than the FLUID excreted in a SEROUS EXUDATE
What is a more common name for NECROTIC DEBRIS?
Pus
What likely conclusion can be drawn from the presence of PURULENT EXUDATE?
There is likely a bacterial infct
What would result in a HEMORRHAGIC EXUDATE? IS this a mild, moderate, or severe INJURY?
Severed BVs, lots of RBCs present.
Severe
What is a MEMBRANOUS EXUDATE?
NECROTIC CELLS enmeshed in FIBROPURULENT EXUDATE
This only appears to be in a membrane = PSEUDOMEMBRANOUS
What is formed by FIBRINOUS EXUDATE? Why is it formed?
Forms a sticky mesh d/t inc amounts of FIBRINOGEN
Are SYSTEMIC MNFTs specific or non-specific? Why might this be more or less helpful?
Non-specific. Less helpful because non-specific mnfts provide less info about the INJURY (where, what, why)
Give 4 examples of SYSTEMIC mnfts
1) Headache
2) Malaise
3) Fatigue
4) Fever
Is fever a deliberate response?
No, it is a side-effect of something
2 benefits of fever
1) Inhibits growth and reproduction of PATHOGENS
2) Enhances PHAGOCYTOSIS and IR
What causes fever?
PYROGENS
How are PYROGENS brought into/released in the body?
Released by BACTERIA
Are PYROGENS ENDOGENOUS or EXOGENOUS? Explain
EXOGENOUS although they are released in the body, the BACTERIA they are released by come from outside the body
What would characterize an ENDOGENOUS substance?
ENDOGENOUS substances come from inside the body, or own CELLS
2 kinds of ENDOGENOUS substances
1) INTERLEUKIN (IL)
2) TUMOR NECROSIS FACTOR (TNF)
