Sept. 11, 2019 Flashcards
In 1 sentance, describe INFLAMMATION
A localized VASCULAR response to INJURY
Is INFLAMMATION more geared towards defense or healing?
Both!
What makes up VASCULAR TISSUE?
BLOOD and BLOOD VESSELS
“itis” at the end of a word indicates what?
INFLAMMATION
Can a CELL become INFLAMED?
No
3 main aims of INFLAMMATION?
1) Localize injurious agents
2) Restrict and remove PATHOGENS
3) Assist w healing
Foreign agents, CELLS, and debris must be removed before ________ can take place.
Healing
Explain ACUTE INFLAMMATION
Has a quick/immediate onset, short duration, and precedes the immune response
Which GRANULOCYTE is predominantly involved in ACUTE INFLAMMATION?
NEUTROPHILS
Explain CHRONIC INFLAMMATION
Long term (could last for weeks or years), is self-maintaining
Which CELLS are predominantly involved in CHRONIC INFLAMMATION?
LYMPHOCYTES and MACROPHAGES
What is ANGIOGENESIS?
The formation of new BLOOD VESSELS (BV)
What is FIBROSIS?
The formation excess FIBROUS CONNECTIVE TISSUE (CT)
What is NECROSIS?
CELL death in an ORGAN or TISSUE caused by external factors
Which 2 responses are involved in ACUTE INFLAMMATION?
1) VASCULAR
2) CELLULAR
Does HEMOSTASIS happen quickly or slowly after an injury?
Quickly
What is HEMOSTASIS?
The stoppage of bleeding
When would VASOCONSTRICTION (VASOCON) occur following an injury?
Stat after injury to minimize B loss
Which INFLAMMATORY MEDIATORS (INFLM MED) are released during an ACUTE response?
HISTAMINES and PROSTAGLANDINS
Give 2 effects of INFLM MEDs
1) VASODILATION
2) Pain
Explain the role of VASODILATION (VASODIL) in an INFLM response
VASODIL causes HYPEREMIA, ERYTHEMA, warmth, inc. PERMEABILITY
What is HYPEREMIA?
An excess or increase of B
What is ERYTHEMA?
Redness
What effect does inc PERMEABILITY have on BVs?
More particles, referred to as EXUDATE, are able to leave the BV because of the inc PERMEABILITY
What is in EXUDATE?
Fluid, CELLs, PROTEINS
Swelling is a side effect of…
…inc PERMEABILITY
What is a benefit of pain?
Pain will result in immobilization to reduce movement and therefore reduce the pain
The ROULEAU formation of RBCs will cause what?
B flow to slow down
Explain DIAPEDESIS
The process of EXUDATE leaving a BV d/t inc PERMEABLITY
Explain TRANSMARGINATION
The process of EXUDATE leaving a BV d/t inc PERMEABLITY
Explain EMIGRATION
The process of EXUDATE leaving a BV d/t inc PERMEABLITY
What is the result of INFLM MEDs in the CELLULAR response?
Attracting NEUTROPHILS and othe WBCs to the site of INJURY using the process of CHEMOTAXIS
The adhesion molecule SELECTIN aids in what process?
MARGINATION
