Oct. 28, 2019 Flashcards
What disease precedes the development of RHEUMATIC HEART DISEASE (RHD)?
RHEUMATIC FEVER (RF)
What is RF?
An immune-mediated, multi-system, inflm disease
What is a result of immune based destruction?
Causes inflm
“When there is inflm, there is always..?
…some degree of tissue damage.”
What age population is usually affected by RF?
Usually children (~3% 5-15 yr olds)
Overview of how RF is dev?
- First, individual contracts STREP THROAT
- Abs are produced to combat STREP
- Abs persist is the body, even after STREP is all gone
- 1-4 weeks later Abs target self Ags in the HEART, joints, CNS, and integument
What form of AUTO-IMMUNITY is RF an example of?
MOL MIMICRY
What is RHD?
An inflm disease of the HEART, immune mediated inflm of VALVES, MYOCARDIUM, and PERICARDIUM
What is meant by the term “self-limiting disease”?
Referring to a disease that doesn’t necessarily require interventions to treat, will run its course and be gone
The self-limiting, ACUTE form of RHD requires:
Monitoring
If RHD is CHRONIC, this will result in:
Severe CARDIAC damage
One word to describe the diagnosing process for RHD?
Fuckin’ complex (oops that was two words ;P)
What is one important mnft of RHD?
Inflm in the HEART
What does inflm in the HEART result in?
(lots of problems, but in this case) dec CO
Diagnostic tests for RHD?
- CBC and differential
- CRP
- ESR
- Serology
- Echo
What is ESR?
ERYTHROCYTE SEDIMENTATION RATE, measures the rate at which RBCs settle
What may cause the ESR to be shorter?
If there are many PROTEINS present, the RBCs will settle faster
5 Tx for RHD?
1) Antibiotics (for the strep)
2) Anti-inflms
3) Immunosuppressants
4) Rest
5) Tx of complications that arise
Which antibiotics would you give for RDH?
- Penicillin
- Erythromycin
What would you give for immunosuppressant in RDH? Why?
Steroids, this will suppress the IR, inflm, and pain
What is the benefit of rest for Tx of RHD? How long for bedrest is suggested?
This will dec the CARDIAC workload, suggested bedrest for 4-5 weeks
CONGESTIVE HEART FAILURE (CHF) is not:
Its not a disease, this is the failure of an organ. Granted, something has to lead to this failure, and that factor could very well be a disease
CHF is a __________ of inadeq CARDIAC Fx
Syndrome
6 things that *usually cause CHF:
1) MI
2) VALVE DISEASE
3) CARDIOMYOPATHY
4) Uncontrolled HTN
5) CAD
6) Risk factors (see Porth pg 626)