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K4 - IBI > Seminarium - ANA > Flashcards

Seminarium - ANA Flashcards

1
Q

När beställs ANA?

A

Misstanke om inflammatorisk systemsjukdom eller utredning av oklar leverpåverkan

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2
Q

Vad är HEp2-celler?

A

Humanepitelcell

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3
Q

Hur är processen för ANA?

A
  1. Mikroskop med HEp2 som inkuberas med patientens serum
  2. Patienten kan ha antikropp som binder till antigen hos HEp2
  3. FITC med anti-humant IgG som kan binda till antikropp
  4. Fluroscerar med specifik våglängd
  5. Nivån autoantikroppar benämns titer och bestäms genom friska blodgivare
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4
Q

Vad associeras homogent mönster till?

A

Kromatinassocierat antigen - dsDNA, histoner, nukleoler

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5
Q

Vad associeras kornigt mönster till?

A

Extrakromosomala kärnantigen - snRNP, SS-A, Scl-70

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6
Q

Vad associeras nukleolärt mönster till?

A

Antigen är fibrallin, RNA-polymeras 1, PM-Scl, SS-B

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7
Q

Vad associeras centrumet mönster till?

A

Kromosomala peptider

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8
Q

Vilken metod kan ANA analyseras med?

A

ELISA

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K4 - IBI (31 decks)

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