S3E3: Rheum

Question 1

Hydroxychlorquine

Answer 1

Immunomodulator

Question 2

Sulfasalasine

Answer 2

Immunomodulator

Question 3

Methotrexate

Answer 3

Immunosuppressant

Question 4

leflunomide

Answer 4

Immunosuppressant

Question 5

cyclophosphamide

Answer 5

Immunosuppressant

Question 6

cyclosporine

Answer 6

Immunosuppressant

Question 7

azathioprine

Answer 7

Immunosuppressant

Question 8

mycophenlate

Answer 8

Immunosuppressant

Question 9

Infliximab (remicade)

Answer 9

TNF-alpha inhibitor

Question 10

Entanercept

Answer 10

TNF-alpha inhibitor

Question 11

Adalimumab (humira)

Answer 11

TNF-alpha inhibitor

Question 12

Golimumab

Answer 12

TNF-alpha inhibitor

Question 13

Certolizumab

Answer 13

TNF-alpha inhibitor

Question 14

Abatacept

Answer 14

Inhibit T cell activation

Question 15

Rituximab

Answer 15

Inhibit cell cycle initiation

Question 16

Anakinra

Answer 16

IL-1 inhibitor

Question 17

Tocilizumab

Answer 17

IL-6 inhibitor

Question 18

Tofacitinib (Xelganz)

Answer 18

JAK inhibitor

Question 19

colchicine

Answer 19

Interrupts MSU deposition

Question 20

probenecid

Answer 20

uricosuric agent

Question 21

isosartan

Answer 21

uricosuric agent

Question 22

fenobrate

Answer 22

uricosuric agent

Question 23

allopurinol

Answer 23

xanthine oxidase inhibitor (lowers uric acid)

Question 24

febuxistat

Answer 24

xanthine oxidase inhibitor (lowers uric acid)

Question 25

Gout tx: Prevention

Answer 25

low dose colchicine + low dose NSAID

Question 26

Gout tx: Acute (for mild and mod)

Answer 26

Mild attack: monotherapy (NSAID or colchicine or steroid)

Mod attack: colchicine + either NSAID or steroid

Question 27

Gout tx: drugs to lower uric acid

Answer 27

Allopurinol or fubuxistat

Question 28

RA tx (for mild, mod, and systemic sx)

Answer 28

Mild: NSAIDs
Mod: MTX 1st. Then add TNF-alpha inhibitor.
Systemic sx: hydroxychloroquine.

Question 29

DMARDs

Answer 29

Immunomodulators
Immunosuppressants
Biologics (TNF-i, -mabs, -JAK, IVIG)