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Pharm > S2E4: Gonadal hormones > Flashcards

S2E4: Gonadal hormones Flashcards

1
Q

Venlafaxine (effexor), fluoxetine (prozac), paroxetine (paxil), sertraline (zoloft)

A

SSRI tx for vasomotor sx

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2
Q

progesterone route of administration

A

IM only

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3
Q

medroxyprogesterone (provera)

A

progesterone

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4
Q

megestrol aceate (megace)

A

progesterone

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5
Q

norethynodrel

A

progesterone

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6
Q

levonorgestrel (norplant)

A

progesterone

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7
Q

norethindrone

A

progesterone

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8
Q

ethynodiol

A

progesterone

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9
Q

norgestrel (ovrette)

A

progesterone

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10
Q

tamoxifen (nolvadex)

A

Estrogen antagonist (premenopausal pt w estrogen-receptor + breast CA tx)

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11
Q

toremifene (fareston)

A

Estrogen antagonist (post menopausal pt estrogen-receptor + breast CA tx)

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12
Q

raloxifene (evista)

A

Estrogen antagonist (osteoporosis prevention)

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13
Q

clomiphene (clomid)

A

Inhibits estrodiol negative feedback, increasing FSH/LH –> increased estrogen. Use in PCOS.

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14
Q

Mifepristone (RU486 or mifeprex)

A

Progestin antagonist, luteolytic.

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15
Q

danazol (danocrine)

A

inhibits FSH/LH, decreases ovarian fnx. Endometriosis tx.

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16
Q

Testosterone, DHT

A

natural androgens/anabolic steroids

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17
Q

testosterone propionate

A

injectable synthetic steroid

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18
Q

testosterone cypionate

A

injectable synthetic steroid

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19
Q

methyltestosterone

A

PO synthetic steroid

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20
Q

fluoxymesterone

A

PO synthetic steroid

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21
Q

-fen(e)

A

estrogen antagonist

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22
Q

finasteride (proscar)

A

5-alpha reductase inhibitor (antiandrogen). BPH, prostate CA.

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23
Q

dutasteride (avodart)

A

5-alpha reductase inhibitor (antiandrogen). BPH, prostate CA.

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24
Q

flutamide (eulexin)

A

5-alpha reductase inhibitor (antiandrogen). Prostate CA

25
Q

OCP DI

A

anti-convulsants (phenytoin, phenobarbital, carbamazepine, oxcarbazepine, lamotrigine, primidone, topiramate)
abx (rifampin)
St. John’s wort

26
Q

implanon

A

progestin coated, sub q. Effective 3 yrs.

27
Q

medroxyprogesterone IM (depo provera)

A

q90d. Progestin only.

* *black box: reduced BMD in Lspine >5 yrs. reversible in 4 yrs.

28
Q

norgestrel (minipill)

A

oral progesterone.

29
Q

norethindrone (minipill)

A

oral progesterone.

30
Q

ethinyl estradiol + norethindrone/levonorgestrel/norgestrel/

norethinedrone/ ethynodiol/norgestimate/ desogestrel/drospirenone

A

combination estrogen + progestin

31
Q

monophasic combo dose

A

constant dose of estrogen/progestin q21d, then 7 days placebo (withdrawal bleeding). 28 day pack.

32
Q

biphasic

A

amount of estrogen/progestin changes 1/3rd of the way through cycle

33
Q

triphasic

A

amount of estrogen/progestin changes qweek (7/7/7)

34
Q

quadriphasic

A

four varying amounts throughout monthly pack

35
Q

same day start

A

take 1st active pill on first day of menses

36
Q

sunday start

A

take 1st active pill first sunday after menses begins.

BUM for 1 week-1 mo

37
Q

quick start

A

take 1st active pill when rx filled (regardless of menses).

BUM for 1 week-1 mo

38
Q

miss 1 pill

A

no BUM

39
Q

miss 2 pills, week 1 or 2

A

take both pills when you remember (2 pills for 2 days). BUM x7d.

40
Q

miss 2 pills, week 3

A

start new pack + BUM x7d.

If Sunday start, continue old pack until Sun, then start new pack. BUM x7d.

41
Q

91 day oral combo

A

estrogen and progesterone combo for 12 weeks, then 1 week of placebo or estrogen.

42
Q

combined transdermal patch

A

topical estrogen/progestin each week for 3 weeks, then remove for 1 week.
**black box: increased estrogen exposure

43
Q

missed transdermal patch

A

24 hrs: patch is new “day 1”, BUM x7d.

44
Q

vaginal ring (nuvaring)

A

3 weeks estrogen/progestin, removed for 1 week.

45
Q

Missed nuvaring

A

3 hrs: reinsert, BUM x7d.

46
Q

levongesterel IUD (Mirena)

A

lasts 5 yrs.
As IUD: prevents implantation
Progestin: thickens cervical mucus, thins endometrium, inhibits sperm motility

47
Q

copper IUD (Copper-T)

A

lasts 10 yrs.
Cu inhibits sperm motility.
Can be emergency contraception.

48
Q

High-dose estrogen/progestin

A

emergency contraception.

49
Q

Emergency contraception dosing of Ovral

A

2 pills immediately, 2 pills 12 hrs later

50
Q

Emergency contraception dosing of low-ogestrel

A

4 pills immediately, 4 pills 12 hrs later

51
Q

Emergency contraception dosing of tri- rx (trivor, tri-levelen, triphasil)

A

4 pills immediately, 4 pills 12 hrs later

52
Q

Emergency contraception dosing of alesse, levelite, lessina

A

5 pills immediately, 5 pills 12 hrs later

53
Q

ovral

A

High-dose estrogen/progestin

54
Q

ovrette

A

progestin only emergency contraception (20 pills immediately, 20 pills 12 hrs later.

55
Q

Plan B (levonorgestrel 0.75 mg)

A

emergency contraception. Take 2 pills 12 hrs apart

56
Q

Plan B one step (levonorgestrel 1.5 mg)

A

emergency contraception

57
Q

emergency contraception time frame

A

High dose estrogen/progestin, or progesterone only: within 120 hrs.
Copper IUD: within 5 days

58
Q

Copper IUD

A

Most effective (>99%), but DONT put in pregnant uterus.

Pharm (37 decks)

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