S3E1: Neurodegenerative dz Flashcards
levodopa
- increases DA levels
- DA precursor
carbidopa
peripheral dopa decarboxylase inhibitor
Carbidopa + levodopa (Sinemet): pros
- lower dose of levodopa
- fewer peripheral effects (N/V)
- more DA effect in CNS
Clozaril
Antipsychotic. Use if psychotic pt needs levodopa
Amantadine use
Antiviral and anti-parkinsons rx.
- increases release of DA (improves tremor, bradykinesia, rigidity)
- use to tx dyskinesia SE of levodopa
Wearing-off (of levodopa) tx
- increase dose/frequency of levodopa
- add DA agonist
- add catechol-O-methyl-transferase (COMT) inhibitor
Rasagiline (azilect)
MAO B inhibitor
Selegiline (eldepryl)
MAO B inhibitor. Increases DA levels
tolcapone (Tasmar)
COMT inhibitor
entacapone (Comtan)
COMT inhibitor
bromocriptine (parlodex)
DA receptor agonist
ropinirole (requip)
DA receptor agonist
apomorphine
DA receptor agonist
benztropine (Cogentin)
ACh receptor antagonist
trihexyphenidyl (artane)
ACh receptor antagonist
drugs that can cause parkinsonian syndrome
- haloperidol
- metoclopramide (reglan)
- phenothiazines (like compazine)
postural tremor tx
- propranolol
- primidone (barbiturate)
- topiramate (anticonvulsant)
tx of tics
haloperidol (if severe)
RLS tx
- DA receptor agonists (ropinirole)
2. levodopa or benzos or opiates
donepezil (aricept)
- centrally acting cholinesterase inhibitor
- alzheimers tx
tacrine (cognex)
- centrally acting cholinesterase inhibitor
- alzheimers tx
rivastigmine (exelon)
- reversible cholinesterase inhibitor
- alzheimers tx
galantamine (razadyne)
- reversible cholinesterase inhibitor
- alzheimers tx
memantine (namenda)
-alzheimers tx