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Pharm > S3E1: Neurodegenerative dz > Flashcards

S3E1: Neurodegenerative dz Flashcards

1
Q

levodopa

A
  • increases DA levels

- DA precursor

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2
Q

carbidopa

A

peripheral dopa decarboxylase inhibitor

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3
Q

Carbidopa + levodopa (Sinemet): pros

A
  • lower dose of levodopa
  • fewer peripheral effects (N/V)
  • more DA effect in CNS
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4
Q

Clozaril

A

Antipsychotic. Use if psychotic pt needs levodopa

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5
Q

Amantadine use

A

Antiviral and anti-parkinsons rx.

  • increases release of DA (improves tremor, bradykinesia, rigidity)
  • use to tx dyskinesia SE of levodopa
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6
Q

Wearing-off (of levodopa) tx

A
  • increase dose/frequency of levodopa
  • add DA agonist
  • add catechol-O-methyl-transferase (COMT) inhibitor
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7
Q

Rasagiline (azilect)

A

MAO B inhibitor

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8
Q

Selegiline (eldepryl)

A

MAO B inhibitor. Increases DA levels

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9
Q

tolcapone (Tasmar)

A

COMT inhibitor

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10
Q

entacapone (Comtan)

A

COMT inhibitor

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11
Q

bromocriptine (parlodex)

A

DA receptor agonist

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12
Q

ropinirole (requip)

A

DA receptor agonist

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13
Q

apomorphine

A

DA receptor agonist

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14
Q

benztropine (Cogentin)

A

ACh receptor antagonist

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15
Q

trihexyphenidyl (artane)

A

ACh receptor antagonist

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16
Q

drugs that can cause parkinsonian syndrome

A
  • haloperidol
  • metoclopramide (reglan)
  • phenothiazines (like compazine)
17
Q

postural tremor tx

A
  • propranolol
  • primidone (barbiturate)
  • topiramate (anticonvulsant)
18
Q

tx of tics

A

haloperidol (if severe)

19
Q

RLS tx

A
  1. DA receptor agonists (ropinirole)

2. levodopa or benzos or opiates

20
Q

donepezil (aricept)

A
  • centrally acting cholinesterase inhibitor

- alzheimers tx

21
Q

tacrine (cognex)

A
  • centrally acting cholinesterase inhibitor

- alzheimers tx

22
Q

rivastigmine (exelon)

A
  • reversible cholinesterase inhibitor

- alzheimers tx

23
Q

galantamine (razadyne)

A
  • reversible cholinesterase inhibitor

- alzheimers tx

24
Q

memantine (namenda)

A

-alzheimers tx

25
MS tx (dz modifying)
- beta interferons - glatiramer acetate (copaxone) - mitoxantrone (novantrone) - natalizumab (tysabri)
26
Huntington tx
- haloperidol (antipsychotic) | - diazepam
27
ALS tx
riluzole (rilutek)
28
Parkinsons tx course
- start with amantadine +/- ACh antagonist - then DA agonist +/- levodopa - then add MAO B or COMTI

Pharm (37 decks)

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