S3E1: Neurodegenerative dz Flashcards
1
Q
levodopa
A
- increases DA levels
- DA precursor
2
Q
carbidopa
A
peripheral dopa decarboxylase inhibitor
3
Q
Carbidopa + levodopa (Sinemet): pros
A
- lower dose of levodopa
- fewer peripheral effects (N/V)
- more DA effect in CNS
4
Q
Clozaril
A
Antipsychotic. Use if psychotic pt needs levodopa
5
Q
Amantadine use
A
Antiviral and anti-parkinsons rx.
- increases release of DA (improves tremor, bradykinesia, rigidity)
- use to tx dyskinesia SE of levodopa
6
Q
Wearing-off (of levodopa) tx
A
- increase dose/frequency of levodopa
- add DA agonist
- add catechol-O-methyl-transferase (COMT) inhibitor
7
Q
Rasagiline (azilect)
A
MAO B inhibitor
8
Q
Selegiline (eldepryl)
A
MAO B inhibitor. Increases DA levels
9
Q
tolcapone (Tasmar)
A
COMT inhibitor
10
Q
entacapone (Comtan)
A
COMT inhibitor
11
Q
bromocriptine (parlodex)
A
DA receptor agonist
12
Q
ropinirole (requip)
A
DA receptor agonist
13
Q
apomorphine
A
DA receptor agonist
14
Q
benztropine (Cogentin)
A
ACh receptor antagonist
15
Q
trihexyphenidyl (artane)
A
ACh receptor antagonist
