Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > S3E1: Neurodegenerative dz > Flashcards

S3E1: Neurodegenerative dz Flashcards

1
Q

levodopa

A
  • increases DA levels

- DA precursor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

carbidopa

A

peripheral dopa decarboxylase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Carbidopa + levodopa (Sinemet): pros

A
  • lower dose of levodopa
  • fewer peripheral effects (N/V)
  • more DA effect in CNS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Clozaril

A

Antipsychotic. Use if psychotic pt needs levodopa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Amantadine use

A

Antiviral and anti-parkinsons rx.

  • increases release of DA (improves tremor, bradykinesia, rigidity)
  • use to tx dyskinesia SE of levodopa
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Wearing-off (of levodopa) tx

A
  • increase dose/frequency of levodopa
  • add DA agonist
  • add catechol-O-methyl-transferase (COMT) inhibitor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rasagiline (azilect)

A

MAO B inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Selegiline (eldepryl)

A

MAO B inhibitor. Increases DA levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

tolcapone (Tasmar)

A

COMT inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

entacapone (Comtan)

A

COMT inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

bromocriptine (parlodex)

A

DA receptor agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ropinirole (requip)

A

DA receptor agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

apomorphine

A

DA receptor agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

benztropine (Cogentin)

A

ACh receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

trihexyphenidyl (artane)

A

ACh receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

drugs that can cause parkinsonian syndrome

A
  • haloperidol
  • metoclopramide (reglan)
  • phenothiazines (like compazine)
17
Q

postural tremor tx

A
  • propranolol
  • primidone (barbiturate)
  • topiramate (anticonvulsant)
18
Q

tx of tics

A

haloperidol (if severe)

19
Q

RLS tx

A
  1. DA receptor agonists (ropinirole)

2. levodopa or benzos or opiates

20
Q

donepezil (aricept)

A
  • centrally acting cholinesterase inhibitor

- alzheimers tx

21
Q

tacrine (cognex)

A
  • centrally acting cholinesterase inhibitor

- alzheimers tx

22
Q

rivastigmine (exelon)

A
  • reversible cholinesterase inhibitor

- alzheimers tx

23
Q

galantamine (razadyne)

A
  • reversible cholinesterase inhibitor

- alzheimers tx

24
Q

memantine (namenda)

A

-alzheimers tx

25
Q

MS tx (dz modifying)

A
  • beta interferons
  • glatiramer acetate (copaxone)
  • mitoxantrone (novantrone)
  • natalizumab (tysabri)
26
Q

Huntington tx

A
  • haloperidol (antipsychotic)

- diazepam

27
Q

ALS tx

A

riluzole (rilutek)

28
Q

Parkinsons tx course

A
  • start with amantadine +/- ACh antagonist
  • then DA agonist +/- levodopa
  • then add MAO B or COMTI

Pharm (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions